Detailed Information on Publication Record
2004
The influence of cannabinoid CB2 receptor agonist JWH 015 on sensitization to methamphetamine in the model of mouse agonistic behaviour
LANDA, Leoš, Alexandra ŠULCOVÁ and Karel ŠLAISBasic information
Original name
The influence of cannabinoid CB2 receptor agonist JWH 015 on sensitization to methamphetamine in the model of mouse agonistic behaviour
Name in Czech
Vliv agonsity kanabinoidních CB2 receptotů na rozvoj sensitizace k metafetaminovým účinkům na agonistické chování myší
Authors
LANDA, Leoš (203 Czech Republic, guarantor), Alexandra ŠULCOVÁ (203 Czech Republic) and Karel ŠLAIS (203 Czech Republic)
Edition
Psychiatrie, Praha, TIGIS s.r.o. 2004, 1211-7579
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30104 Pharmacology and pharmacy
Country of publisher
Czech Republic
Confidentiality degree
není předmětem státního či obchodního tajemství
RIV identification code
RIV/00216224:14110/04:00009923
Organization unit
Faculty of Medicine
Keywords in English
behavioural sensitization;CB2 receptor; methamphetamine; JWH-015; agonistic behaviour; mice
Změněno: 16/5/2005 11:09, prof. MUDr. Alexandra Šulcová, CSc.
V originále
The aim of the present study was to investigate whether the CB2 receptor activity might also be involved in regulation of mouse agonistic behaviour, and in development of sensitivity to methamphetamine.The CB2 agonist JWH-015 given alone to aggressive singly-housed mice at the doses of 0.1, 1.0 and 10.0 mg/kg intraperitoneally 15 min prior to testing inhibited the occurrence of aggressive activities, significantly of tail rattling and threat after the highest dose. The expression of significant sensitization to MET antiaggressive effects was clear after the pre-treatment with 5 MET doses of 1 mg/kg/day and administration of the "challenge dose" of 1 mg/kg after 5 days of withdrawal. However, the pretreatment with JWH (5 daily doses of 1.0 mg/kg) the cross-sensitization to MET "challenge dose" did not produce in the present study.
In Czech
Premedikace opakovým podáním agonisty kanabinoidních CB2 receptorů, JWH 015, nevyvolala zkříženou sensitizaci k antiagresivním účinkům metamfetaminu u myší.