BÉBAROVÁ, Markéta, Peter MATEJOVIČ, Michal PÁSEK, Milena ŠIMURDOVÁ and Jiří ŠIMURDA. Frequency dependence of Ito and INa block in ventricular cardiomyocytes: comparison of the effect of ajmaline and propafenone. In Physiological Research. 2003.
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Basic information
Original name Frequency dependence of Ito and INa block in ventricular cardiomyocytes: comparison of the effect of ajmaline and propafenone
Authors BÉBAROVÁ, Markéta (203 Czech Republic, guarantor, belonging to the institution), Peter MATEJOVIČ (703 Slovakia, belonging to the institution), Michal PÁSEK (203 Czech Republic, belonging to the institution), Milena ŠIMURDOVÁ (203 Czech Republic, belonging to the institution) and Jiří ŠIMURDA (203 Czech Republic, belonging to the institution).
Edition Physiological Research, 2003.
Other information
Original language English
Type of outcome Conference abstract
Field of Study 30105 Physiology
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
RIV identification code RIV/00216224:14110/03:00009516
Organization unit Faculty of Medicine
Keywords in English frequency dependence; transient outward current; sodium current; antiarrhythmic drugs; ajmaline; propafenone; rat
Tags ajmaline, antiarrhythmic drugs, frequency dependence, propafenone, rat, sodium current, transient outward current
Tags International impact, Reviewed
Changed by Changed by: doc. MUDr. Markéta Bébarová, Ph.D., učo 15000. Changed: 19/1/2013 21:44.
Abstract
In contrast to propafenone, ajmaline induces frequency-independent block of INa and Ito. The difference is likely caused by variances in the values of rate constants related to the block of inactivated channels.
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MSM 141100004, plan (intention)Name: Časná diagnostika kardiovaskulárních chorob
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