Frekvenční závislost blokády Ito a INa u komorových srdečních buněk: srovnání vlivu ajmalinu a propafenonu

BÉBAROVÁ, Markéta, Peter MATEJOVIČ, Michal PÁSEK, Milena ŠIMURDOVÁ and Jiří ŠIMURDA. Frekvenční závislost blokády Ito a INa u komorových srdečních buněk: srovnání vlivu ajmalinu a propafenonu. In Program a sborník abstraktů, 79. Fyziologické dny. 2003.

Basic information

• Original name: Frekvenční závislost blokády Ito a INa u komorových srdečních buněk: srovnání vlivu ajmalinu a propafenonu
• Authors: BÉBAROVÁ, Markéta (203 Czech Republic, guarantor, belonging to the institution), Peter MATEJOVIČ (703 Slovakia, belonging to the institution), Michal PÁSEK (203 Czech Republic, belonging to the institution), Milena ŠIMURDOVÁ (203 Czech Republic, belonging to the institution) and Jiří ŠIMURDA (203 Czech Republic, belonging to the institution).
• Edition: Program a sborník abstraktů, 79. Fyziologické dny, 2003.

Other information

• Original language: English
• Type of outcome: Conference abstract
• Field of Study: 30105 Physiology
• Country of publisher: Czech Republic
• Confidentiality degree: is not subject to a state or trade secret
• RIV identification code: RIV/00216224:14110/03:00009517
• Organization unit: Faculty of Medicine
• Keywords in English: frequency dependence; transient outward current; sodium current; antiarrhythmic drugs; ajmaline; propafenone; rat
• Tags: ajmaline, antiarrhythmic drugs, frequency dependence, propafenone, rat, sodium current, transient outward current

Abstract

In contrast to propafenone, ajmaline induces frequency-independent block of INa and Ito. The difference is likely caused by variances in the values of rate constants related to the block of inactivated channels.