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@inproceedings{493026, author = {Bébarová, Markéta and Matejovič, Peter and Pásek, Michal and Šimurdová, Milena and Šimurda, Jiří}, address = {Brno}, booktitle = {Proceedings of symposium: Chronobiological analysis in pathophysiology of cardiovascular system}, keywords = {rate dependence; action potential; action potential voltage clamp; rat; ajmaline}, language = {eng}, location = {Brno}, isbn = {80-7013-394-5}, publisher = {neuveden}, title = {Rate dependent changes of action potential waveform in rat ventricular myocytes. Action potential voltage clamp experiments}, year = {2003} }
TY - JOUR ID - 493026 AU - Bébarová, Markéta - Matejovič, Peter - Pásek, Michal - Šimurdová, Milena - Šimurda, Jiří PY - 2003 TI - Rate dependent changes of action potential waveform in rat ventricular myocytes. Action potential voltage clamp experiments PB - neuveden CY - Brno SN - 8070133945 KW - rate dependence KW - action potential KW - action potential voltage clamp KW - rat KW - ajmaline N2 - Components of the total ionic current responsible for rate-dependent changes of action potential (AP) configuration were analyzed by the AP clamp method in isolated rat ventricular myocytes. The results demonstrate that besides Ca2+-mediated currents, cumulative inactivation of the transient outward current Ito significantly participates on the rate-dependent variability of AP configuration. Under the effect of antiarrhythmic drug ajmaline (30mikromol/l), the fast sodium current INa causes marked changes in the repolarization phase of AP, very likely as a consequence of its use-dependent block. ER -
BÉBAROVÁ, Markéta, Peter MATEJOVIČ, Michal PÁSEK, Milena ŠIMURDOVÁ a Jiří ŠIMURDA. Rate dependent changes of action potential waveform in rat ventricular myocytes. Action potential voltage clamp experiments. In \textit{Proceedings of symposium: Chronobiological analysis in pathophysiology of cardiovascular system}. Brno: neuveden, 2003, 7 s. ISBN~80-7013-394-5.
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