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@inproceedings{493026,
author = {Bébarová, Markéta and Matejovič, Peter and Pásek, Michal and Šimurdová, Milena and Šimurda, Jiří},
address = {Brno},
booktitle = {Proceedings of symposium: Chronobiological analysis in pathophysiology of cardiovascular system},
keywords = {rate dependence; action potential; action potential voltage clamp; rat; ajmaline},
language = {eng},
location = {Brno},
isbn = {80-7013-394-5},
publisher = {neuveden},
title = {Rate dependent changes of action potential waveform in rat ventricular myocytes. Action potential voltage clamp experiments},
year = {2003}
}
TY - JOUR
ID - 493026
AU - Bébarová, Markéta - Matejovič, Peter - Pásek, Michal - Šimurdová, Milena - Šimurda, Jiří
PY - 2003
TI - Rate dependent changes of action potential waveform in rat ventricular myocytes. Action potential voltage clamp experiments
PB - neuveden
CY - Brno
SN - 8070133945
KW - rate dependence
KW - action potential
KW - action potential voltage clamp
KW - rat
KW - ajmaline
N2 - Components of the total ionic current responsible for rate-dependent changes of action potential (AP) configuration were analyzed by the AP clamp method in isolated rat ventricular myocytes. The results demonstrate that besides Ca2+-mediated currents, cumulative inactivation of the transient outward current Ito significantly participates on the rate-dependent variability of AP configuration. Under the effect of antiarrhythmic drug ajmaline (30mikromol/l), the fast sodium current INa causes marked changes in the repolarization phase of AP, very likely as a consequence of its use-dependent block.
ER -
BÉBAROVÁ, Markéta, Peter MATEJOVIČ, Michal PÁSEK, Milena ŠIMURDOVÁ and Jiří ŠIMURDA. Rate dependent changes of action potential waveform in rat ventricular myocytes. Action potential voltage clamp experiments. In \textit{Proceedings of symposium: Chronobiological analysis in pathophysiology of cardiovascular system}. Brno: neuveden, 2003, 7 pp. ISBN~80-7013-394-5.
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