NMR Relaxation Studies of Fast Internal Motions in Nucleic Acids

TRANTÍREK, Lukáš, Erik CAHA and Radovan FIALA. NMR Relaxation Studies of Fast Internal Motions in Nucleic Acids. In Materials Structure. 1st ed. Prague: Czech and Slovak Crystalographic Association, 2003, p. 40-41. ISBN 1211-5894.

Basic information

Original name

NMR Relaxation Studies of Fast Internal Motions in Nucleic Acids

Authors

TRANTÍREK, Lukáš (203 Czech Republic), Erik CAHA (203 Czech Republic) and Radovan FIALA (203 Czech Republic, guarantor)

Edition

1. vyd. Prague, Materials Structure, p. 40-41, 2 pp. 2003

Publisher

Czech and Slovak Crystalographic Association

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Other information

Language

English

Type of outcome

Stať ve sborníku

Field of Study

10403 Physical chemistry

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

RIV identification code

RIV/00216224:14310/03:00009533

Organization unit

Faculty of Science

ISBN

1211-5894

Keywords in English

RNA; dynamics; NMR; spectroscopy; relaxation; molecular dynamics

Tags

dynamics, molecular dynamics, NMR, relaxation, RNA, spectroscopy

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Abstract

V originále

Internal motions of two 14-nt RNA hairpins containing UUCG and GCAA tetraloops were studied by C-13 NMR relaxation and molecular dynamics. While both tetraloops exhibit an increased mobility on the fast time scale, with the GCAA loop we have detected a significant contribution of conformational dynamics on the millisecond to microsecond time scale. This is consistent with the observation that the GNRA family of tetraloops appears more flexible and tolerant of the conformational changes important for molecular recognition.

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Links

LN00A016, research and development project

Name: BIOMOLEKULÁRNÍ CENTRUM Investor: Ministry of Education, Youth and Sports of the CR, Biomolecular Center