NAVRÁTILOVÁ, Hana, Radka OPATŘILOVÁ, Zdeněk KŘÍŽ and Jaroslav KOČA. Enantioselective chromatography and molecular modeling of novel aryloxyaminopropan-2-ols with the alkyl carbamate function. Chirality. 2004, vol. 16, No 3, p. 139-146. ISSN 0899-0042. |
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@article{553682, author = {Navrátilová, Hana and Opatřilová, Radka and Kříž, Zdeněk and Koča, Jaroslav}, article_number = {3}, keywords = {aryloxyaminopropanols; enantioselective HPLC; Chiralcel OD-H; Chiralpak AD; chiral recognition; low-energy conformers; molecular modeling}, language = {eng}, issn = {0899-0042}, journal = {Chirality}, title = {Enantioselective chromatography and molecular modeling of novel aryloxyaminopropan-2-ols with the alkyl carbamate function.}, volume = {16}, year = {2004} }
TY - JOUR ID - 553682 AU - Navrátilová, Hana - Opatřilová, Radka - Kříž, Zdeněk - Koča, Jaroslav PY - 2004 TI - Enantioselective chromatography and molecular modeling of novel aryloxyaminopropan-2-ols with the alkyl carbamate function. JF - Chirality VL - 16 IS - 3 SP - 139-146 EP - 139-146 SN - 08990042 KW - aryloxyaminopropanols KW - enantioselective HPLC KW - Chiralcel OD-H KW - Chiralpak AD KW - chiral recognition KW - low-energy conformers KW - molecular modeling N2 - A series of different racemic aryloxyaminopropan-2-ol derivatives 1a-d-3a-d with potential -adrenergic blocking effects related to propanolol 4 and atenolol 5 was resolved by HPLC using Chiralcel OD-H and Chiralpak AD as chiral stationary phases. Mobile phases consisted of a hexane/alcohol (propan-2-ol or ethanol) mixture doped with a modifier (DEA or TFA). The retention behavior of the compounds depended on the position of the carbamate attached to the aryloxy moiety and on the length of the alkyl residue in the carbamate. Enantiomers of the title compounds were baseline separated with the separation factors and resolutions Rs varying in the range of 1.34-4.55 and 1.50-10.65, respectively. The chromatographic systems developed can be used for the determination of the enantiomeric purity of the title compounds. Molecular modelling using empirical molecular mechanics and ab initio quantum chemistry methods provided low-energy structures in which sites of potential interactions responsible for retention behavior and chiral recognition could be identified ER -
NAVRÁTILOVÁ, Hana, Radka OPATŘILOVÁ, Zdeněk KŘÍŽ and Jaroslav KOČA. Enantioselective chromatography and molecular modeling of novel aryloxyaminopropan-2-ols with the alkyl carbamate function. \textit{Chirality}. 2004, vol.~16, No~3, p.~139-146. ISSN~0899-0042.
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