24hodinová kontrola krevního tlaku a trough/peak ratio retardovaného metoprololu u pacientu s cerstve zjistenou hypertenzí.

RIHACEK, Ivan, Miroslav SOUCEK, Petr FRANA and Tomas KARA. 24hodinová kontrola krevního tlaku a trough/peak ratio retardovaného metoprololu u pacientu s cerstve zjistenou hypertenzí. (24-hour blood pressure control and trough/peak ratio of slow release metoprolole in patients with newly diagnosed hypertension.). Lékarské listy. Praha: Sanoma Magazines Praha, 2003, vol. 4, No 52, p. 28-29. ISSN 0044-1996.

Basic information

• Original name: 24hodinová kontrola krevního tlaku a trough/peak ratio retardovaného metoprololu u pacientu s cerstve zjistenou hypertenzí.
• Name (in English): 24-hour blood pressure control and trough/peak ratio of slow release metoprolole in patients with newly diagnosed hypertension.
• Authors: RIHACEK, Ivan (203 Czech Republic, guarantor), Miroslav SOUCEK (203 Czech Republic), Petr FRANA (203 Czech Republic) and Tomas KARA (203 Czech Republic).
• Edition: Lékarské listy, Praha, Sanoma Magazines Praha, 2003, 0044-1996.

Other information

• Original language: Czech
• Type of outcome: Article in a journal
• Field of Study: 30201 Cardiac and Cardiovascular systems
• Country of publisher: Czech Republic
• Confidentiality degree: is not subject to a state or trade secret
• RIV identification code: RIV/00216224:14110/03:00009542
• Organization unit: Faculty of Medicine
• Keywords in English: metoprolole; hypertension; trough/peak ratio
• Tags: Hypertension, metoprolole, Trough/peak ratio

Abstract

Jednou z dulezitých vlastností nových antihypertenziv je jejich 24hodinová úcinnost. Pokud má lék pomer trough/peak nad 50% muze být podáván jedenkrát denne. Vysetrili jsme 30 pacientu s cerstve zjistenou hypertenzí pred a po 3mesícní lécbe retardovaným metoprololem v prumerné dávce 150mg 1x denne. Krevní tlak (TK) byl meren pomocí 24hodinového ambulantního monitorování podle kritérií WHO. Pro hodntu peak jsme pouzili prumerné hodnoty TK ve 3-6 hodine po uzití metoprololu a pro hodnotu trough prumerný tlak ve 22-24 hodine merení, 30 minut po ranním vstávání a s vyloucením vlivu nemocnicního prostredí. Výsledky: 1. Retardovaný metoprolol snízil 24h systolický TK o 10,4 +- 7,3 mmHg, P < 0,001, 24h diastolický TK o 8,5 +- 5,2 mmHg, P < 0,001, a 24h tepovou frekvenci o 9,6 +- 8,7 tepu/minutu, P < 0,001. 2. Trough/peak pomer retardovaného metoprololu byl 78% pro systolický TK a 72% pro diastolický TK. Závery: 1. Retardovaný metoprolol má hodnotu trough/peak nad 70% a muze být podáván 1x denne. 2. Retardovaný metoprolol podávaný jedenkrát denne statisticky významne snízil hodnoty 24h krevního tlaku a srdecní frekvence.

Abstract (in English)

One of the important characteristic features of the new antihypertensives drugs is its 24-hour effectiveness. If the drug reaches the mean trough/peak over 50% it can be dosed once daily. We evaluated 30 patients with newly diagnosed essential hypertension before and after the 3months of treatment with average dose of 150mg slow release metoprolole once daily. Blood pressure (BP)was measured using 24hour ambulatory blood pressure monitoring according to WHO criteria. For the peak value we used the mean BP from the 3rd - 6th hour after the using of metoprolole, for the trough value the mean BP from the 22nd - 24th hour of the measurement was used, 30 minutes after getting up in the morning and excluding the influence of the hospital surroundings. Results: 1. Metoprolole decreased 24-hour systolic BP by 10,4 +- 7,3 mmHg, P < 0,001, 24-hour diastolic BP by 8,5 +- 5,2 mmHg, P < 0,001, and 24-hour heart rate by 9,6 +- 8,7 beat/minute, P < 0,001. 2. Trough/peak ratio slow release metoprolole is 78% by the systolic BP, and it is 72% by the diastolic BP. Conclusions: 1. Slow release metoprolole has the value trough/peak over 70% and it can be dosed once daily. 2. Slow release metoprolole once daily statistically significant lower 24-hour blood pressure and heart rate.