Detailed Information on Publication Record
2003
Differential effects of c-Fos and v-Fos proteins on v-myb-transformed monoblasts
ZAHRADNÍČKOVÁ, Eva, Sabina ŠEVČÍKOVÁ, Karel SOUČEK and Jan ŠMARDABasic information
Original name
Differential effects of c-Fos and v-Fos proteins on v-myb-transformed monoblasts
Name (in English)
Differential effects of c-Fos and v-Fos proteins on v-myb-transformed monoblasts
Authors
ZAHRADNÍČKOVÁ, Eva (203 Czech Republic), Sabina ŠEVČÍKOVÁ (203 Czech Republic), Karel SOUČEK (203 Czech Republic) and Jan ŠMARDA (203 Czech Republic, guarantor)
Edition
Brno, Memory in Living Systems, p. 73-73, 2003
Publisher
Czechoslovak Biological Society
Other information
Language
Czech
Type of outcome
Stať ve sborníku
Field of Study
Genetics and molecular biology
Country of publisher
Czech Republic
Confidentiality degree
není předmětem státního či obchodního tajemství
RIV identification code
RIV/00216224:14330/03:00008669
Organization unit
Faculty of Informatics
ISBN
80-210-3264-2
Keywords in English
Fos; Myb; proliferation; differentiation; apoptosis
Tags
Změněno: 29/5/2004 17:30, RNDr. JUDr. Vladimír Šmíd, CSc.
V originále
c-Fos and v-Fos proteins as well as v-Jun and c-Jun belong to the proteins forming the AP-1 transcription factor. The AP-1 participates in regulation of proliferation, differentiation and programmed cell death in multiple cell types. In this study we explored the effects of c-Fos and v-Fos proteins on the line of v-myb transformed chicken monoblasts BM2. Both c-Fos and v-Fos proteins were ectopically expressed in BM2 cells. The v-Fos protein induced growth arrest in G0G1-phase of the BM2 cell cycle similarly as c-Jun protein. Interestingly, c-Fos leaved the cell cycle unaffected and rather induced programmed cell death. This effect of c-Fos protein was markedly enhanced in cells cultivated under serum-free conditions. In contrast to Jun proteins, no differentiation promoting effect of c-Fos and v-Fos protein was detected in BM2 cells. These results suggest differential roles of individual components of the AP-1 transcription factor in regulation of differentiation and programmed cell.
In English
c-Fos and v-Fos proteins as well as v-Jun and c-Jun belong to the proteins forming the AP-1 transcription factor. The AP-1 participates in regulation of proliferation, differentiation and programmed cell death in multiple cell types. In this study we explored the effects of c-Fos and v-Fos proteins on the line of v-myb transformed chicken monoblasts BM2. Both c-Fos and v-Fos proteins were ectopically expressed in BM2 cells. The v-Fos protein induced growth arrest in G0G1-phase of the BM2 cell cycle similarly as c-Jun protein. Interestingly, c-Fos leaved the cell cycle unaffected and rather induced programmed cell death. This effect of c-Fos protein was markedly enhanced in cells cultivated under serum-free conditions. In contrast to Jun proteins, no differentiation promoting effect of c-Fos and v-Fos protein was detected in BM2 cells. These results suggest differential roles of individual components of the AP-1 transcription factor in regulation of differentiation and programmed cell.
Links
| GA301/01/0040, research and development project |
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| GA301/03/1055, research and development project |
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