Swm1/Apc13 is an evolutionarily conserved subunit of the anaphase-promoting complex stabilizing the association of Cdc16 and Cdc27

SCHWICKART, Martin, Jan HAVLIŠ, Bianca HABERMANN, Aliona BOGDANOVA, Alain CAMASSES, Tobias OELSCHLAEGEL, Andrej SHEVCHENKO and Wolfgang ZACHARIAE. Swm1/Apc13 is an evolutionarily conserved subunit of the anaphase-promoting complex stabilizing the association of Cdc16 and Cdc27. Molecular and Cellular Biology. Washington, D.C.: ASM, 2004, vol. 24, No 8, p. 3562-3576. ISSN 0270-7306.

Basic information

• Original name: Swm1/Apc13 is an evolutionarily conserved subunit of the anaphase-promoting complex stabilizing the association of Cdc16 and Cdc27
• Name (in English): Swm1/Apc13 is an evolutionarily conserved subunit of the anaphase-promoting complex stabilizing the association of Cdc16 and Cdc27
• Authors: SCHWICKART, Martin, Jan HAVLIŠ, Bianca HABERMANN, Aliona BOGDANOVA, Alain CAMASSES, Tobias OELSCHLAEGEL, Andrej SHEVCHENKO and Wolfgang ZACHARIAE.
• Edition: Molecular and Cellular Biology, Washington, D.C. ASM, 2004, 0270-7306.

Other information

• Type of outcome: Article in a journal
• Confidentiality degree: is not subject to a state or trade secret
• Impact factor: Impact factor: 7.822
• Organization unit: Faculty of Science
• UT WoS: 000220685400044
• Tags: International impact, Reviewed

Abstract (in English)

The anaphase-promoting complex (APC/C) is a large ubiquitin-protein ligase which controls progression through anaphase by triggering the degradation of cell cycle regulators such as securin and B-type cyclins. The APC/C is an unusually complex ligase containing at least 10 different, evolutionarily conserved components. In contrast to APC/C's role in cell cycle regulation little is known about the functions of individual subunits and how they might interact with each other. Here, we have analyzed Swm1/Apc13, a small subunit recently identified in the budding yeast complex. Database searches revealed proteins related to Swm1/Apc13 in various organisms including humans. Both the human and the fission yeast homologues are associated with APC/C subunits, and they complement the phenotype of an SWM1 deletion mutant of budding yeast. Swm1/Apc13 promotes the stable association with the APC/C of the essential subunits Cdc16 and Cdc27. Accordingly, Swm1/Apc13 is required for ubiquitin ligase activity in vitro and for the timely execution of APC/C-dependent cell cycle events in vivo.