J 2004

Swm1/Apc13 is an evolutionarily conserved subunit of the anaphase-promoting complex stabilizing the association of Cdc16 and Cdc27

SCHWICKART, Martin, Jan HAVLIŠ, Bianca HABERMANN, Aliona BOGDANOVA, Alain CAMASSES et. al.

Basic information

Original name

Swm1/Apc13 is an evolutionarily conserved subunit of the anaphase-promoting complex stabilizing the association of Cdc16 and Cdc27

Name (in English)

Swm1/Apc13 is an evolutionarily conserved subunit of the anaphase-promoting complex stabilizing the association of Cdc16 and Cdc27

Authors

SCHWICKART, Martin, Jan HAVLIŠ, Bianca HABERMANN, Aliona BOGDANOVA, Alain CAMASSES, Tobias OELSCHLAEGEL, Andrej SHEVCHENKO and Wolfgang ZACHARIAE

Edition

Molecular and Cellular Biology, Washington, D.C. ASM, 2004, 0270-7306

Other information

Type of outcome

Článek v odborném periodiku

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 7.822

Organization unit

Faculty of Science

UT WoS

000220685400044

Tags

International impact, Reviewed
Změněno: 2/7/2009 18:59, doc. Mgr. Jan Havliš, Dr.

Abstract

In English

The anaphase-promoting complex (APC/C) is a large ubiquitin-protein ligase which controls progression through anaphase by triggering the degradation of cell cycle regulators such as securin and B-type cyclins. The APC/C is an unusually complex ligase containing at least 10 different, evolutionarily conserved components. In contrast to APC/C's role in cell cycle regulation little is known about the functions of individual subunits and how they might interact with each other. Here, we have analyzed Swm1/Apc13, a small subunit recently identified in the budding yeast complex. Database searches revealed proteins related to Swm1/Apc13 in various organisms including humans. Both the human and the fission yeast homologues are associated with APC/C subunits, and they complement the phenotype of an SWM1 deletion mutant of budding yeast. Swm1/Apc13 promotes the stable association with the APC/C of the essential subunits Cdc16 and Cdc27. Accordingly, Swm1/Apc13 is required for ubiquitin ligase activity in vitro and for the timely execution of APC/C-dependent cell cycle events in vivo.