| PÁSEK, Michal, Georges CHRISTÉ and Jiří ŠIMURDA. A quantitative model of the cardiac ventricular cell incorporating the transverse-axial tubular system. General Physiology and Biophysics. R&D print, Bratislava, 2003, vol. 22, No 3, p. 355-368. ISSN 0231-5882. |
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@article{554790,
author = {Pásek, Michal and Christé, Georges and Šimurda, Jiří},
article_number = {3},
keywords = {cardiac cell; tubular system; quantitative modelling},
language = {eng},
issn = {0231-5882},
journal = {General Physiology and Biophysics},
title = {A quantitative model of the cardiac ventricular cell incorporating the transverse-axial tubular system},
volume = {22},
year = {2003}
}
TY - JOUR
ID - 554790
AU - Pásek, Michal - Christé, Georges - Šimurda, Jiří
PY - 2003
TI - A quantitative model of the cardiac ventricular cell incorporating the transverse-axial tubular system
JF - General Physiology and Biophysics
VL - 22
IS - 3
SP - 355-368
EP - 355-368
PB - R&D print, Bratislava
SN - 02315882
KW - cardiac cell
KW - tubular system
KW - quantitative modelling
N2 - The role of the transverse-axial tubular system (TATS) in electrical activity of cardiac cells has not been investigated quantitatively. In this study a mathematical model including the TATS and differential distribution of ionic transfer mechanisms in peripheral and tubular membranes was described. A model of ventricular cardiac cell described by Jafri et al. (1998) was adopted and slightly modified to describe ionic currents and Ca2+ handling. Changes of concentrations in the lumen of the TATS were computed from the total of transmembrane ionic fluxes and ionic exchanges with the pericellular medium. Long-term stability of the model was attained at rest and under regular stimulation. Depletion of Ca2+ by 12.8 % and accumulation of K+ by 4.7 % occurred in the TATS-lumen at physiological conditions and at a stimulation frequency of 1 Hz. The changes were transient and subsided on repolarization within 800 ms (Ca2+) and 300 ms (K+). Nevertheless, the course of action potentials remained virtually unaltered. Simulations of voltage clamp experiments demonstrated that variations in tubular ionic concentrations were detectable as modulation of the recorded membrane currents.
ER -
PÁSEK, Michal, Georges CHRISTÉ and Jiří ŠIMURDA. A quantitative model of the cardiac ventricular cell incorporating the transverse-axial tubular system. \textit{General Physiology and Biophysics}. R\&{}D print, Bratislava, 2003, vol.~22, No~3, p.~355-368. ISSN~0231-5882.
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