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@inproceedings{554942,
author = {Pásek, Michal and Christé, Georges and Šimurda, Jiří},
address = {Praha},
booktitle = {Engineering mechanics 2003.},
keywords = {cardiac cell; tubular system; quantitative modelling},
language = {eng},
location = {Praha},
isbn = {80-86246-18-3},
pages = {1-9},
publisher = {UTAM AV ČR},
title = {Quantitative modelling of effect of transverse - axial tubular system on electrical activity of cardiac cells: Development of model II.},
year = {2003}
}
TY - JOUR
ID - 554942
AU - Pásek, Michal - Christé, Georges - Šimurda, Jiří
PY - 2003
TI - Quantitative modelling of effect of transverse - axial tubular system on electrical activity of cardiac cells: Development of model II.
PB - UTAM AV ČR
CY - Praha
SN - 8086246183
KW - cardiac cell
KW - tubular system
KW - quantitative modelling
N2 - In this work, we present a new version of cardiac ventricular cell model incorporating the transverse - axial tubular system. The improvements include reformulated description of L-type Ca2+ channel, of Ca2+ induced Ca2+ release from sarcoplasmic reticulum, of intracellular Ca2+ buffering and incorporation of potassium currents Ito, IK(Na) and IK(ATP). In comparison with the previous model (Pásek et al., 2002), the steady state simulations revealed more profound changes of tubular ionic concentration (12.8 % for Ca2+ and 4.7 % for K+ at 1 Hz). The refined model will be used for more exact quantitative exploration of the effect of transverse - axial tubular system on cellular electrical activity and excitation - contraction coupling.
ER -
PÁSEK, Michal, Georges CHRISTÉ and Jiří ŠIMURDA. Quantitative modelling of effect of transverse - axial tubular system on electrical activity of cardiac cells: Development of model II. In \textit{Engineering mechanics 2003.}. Praha: UTAM AV ČR, 2003, p.~1-9. ISBN~80-86246-18-3.
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