Prognostic factors of the Pharynx and supraglottic Carcinoma

KOSTŘICA, Rom, Pavel SMILEK, Jan ROTTENBERG, Karel VESELÝ, Ladislav DUŠEK and Jiří HLOŽEK. Prognostic factors of the Pharynx and supraglottic Carcinoma. In HNO Infromationen. Stuttgart: Karl Demetr Verlag im Georg Thieme VErlag, 2004, p. 139. ISBN 03 44-93 19.

Basic information

• Original name: Prognostic factors of the Pharynx and supraglottic Carcinoma
• Name (in English): Prognostic factors of the Pharynx and supraglottic Carcinoma
• Authors: KOSTŘICA, Rom (203 Czech Republic), Pavel SMILEK (203 Czech Republic, guarantor), Jan ROTTENBERG (203 Czech Republic), Karel VESELÝ (203 Czech Republic), Ladislav DUŠEK (203 Czech Republic) and Jiří HLOŽEK (203 Czech Republic).
• Edition: Stuttgart, HNO Infromationen, p. 139-139, 2004.
• Publisher: Karl Demetr Verlag im Georg Thieme VErlag

Other information

• Original language: Czech
• Type of outcome: Proceedings paper
• Field of Study: 30200 3.2 Clinical medicine
• Country of publisher: Canada
• Confidentiality degree: is not subject to a state or trade secret
• RIV identification code: RIV/00216224:14110/04:00010082
• Organization unit: Faculty of Medicine
• ISBN: 03 44-93 19
• Keywords in English: Prognosis of head and neck carcinoma - DNA content - Ki-67

Abstract

The analysis was carried out with a set of 60 patients suffering from carcinoma of the pharynx and supraglottis treated at the Clinic of Otorhinolaryngology and Head and Neck Surgery in Brno within 1991 - 1999. Besides routine examinations, flow cytometric analysis of DNA was performed and Ki-67 marker was established by means of immunohistochemistry. The evaluation of kinetic parameters of the cellular cycle has revealed quite clearly the significantly lower share of SPF in tumors with poor prognosis. Tumors with direct progression immediately after treatment have shown statistically significantly higher share of cells in G2/M phase.

Abstract (in English)

The analysis was carried out with a set of 60 patients suffering from carcinoma of the pharynx and supraglottis treated at the Clinic of Otorhinolaryngology and Head and Neck Surgery in Brno within 1991 - 1999. Besides routine examinations, flow cytometric analysis of DNA was performed and Ki-67 marker was established by means of immunohistochemistry. The evaluation of kinetic parameters of the cellular cycle has revealed quite clearly the significantly lower share of SPF in tumors with poor prognosis. Tumors with direct progression immediately after treatment have shown statistically significantly higher share of cells in G2/M phase.

Links

• MSM 141100003, plan (intention): Name: Zevní prostředí - karcinogeneze - onkologie

Investor: Ministry of Education, Youth and Sports of the CR, Environment - carcinogenesis - oncology