Analytical Aplication of Dipon Ligand

D 2003

Analytical Aplication of Dipon Ligand

SVOBODOVÁ, Ivona, Přemysl LUBAL, Jiří MALEČEK, Jan KOTEK, Petr HERMANN et. al.

Basic information

Original name

Analytical Aplication of Dipon Ligand

Authors

SVOBODOVÁ, Ivona (203 Czech Republic), Přemysl LUBAL (203 Czech Republic, guarantor), Jiří MALEČEK (203 Czech Republic), Jan KOTEK (203 Czech Republic), Petr HERMANN (203 Czech Republic), Josef HAVEL (203 Czech Republic) and Ivan LUKEŠ (203 Czech Republic)

Edition

Gdansk, Book of Abstracts of XXVIII International Symposium on Macrocyclic Chemistry, Gdansk, Poland, July 13-18 2003, p. P117, 1 pp. 2003

Publisher

Gdansk University of Technology

Other information

Language

English

Type of outcome

Stať ve sborníku

Field of Study

10406 Analytical chemistry

Country of publisher

Poland

Confidentiality degree

není předmětem státního či obchodního tajemství

RIV identification code

RIV/00216224:14310/03:00008743

Organization unit

Faculty of Science

ISBN

83-914495-6-4

Keywords in English

1;4;8;11-tetraazacyclotetradecane-1;8-bis(methylphosphonic) acid; kinetic determination; volumetric determination; capillary zone electrophoresis determination

Abstract

V originále

Complexation reactions of macrocyclic ligands are widely utilized in analytical chemistry. Such ligands show high ion selectivity or catalytic activity of their complexes on chemical reactions. They can be applied for determination of inorganic as well as organic cations, anions and neutral compounds. In this work, the possible applications of macrocyclic ligand 1,4,8,11-tetraazacyclotetradecane-1,8-bis(methylphosphonic) acid, (dipon) in analytical chemistry were examined. The ligand exhibits extraordinary thermodynamic and kinetic stability of copper(II) complex in comparison to other metal ions. Three possibilities of utilization of dipon for copper analysis were proposed: i)kinetic determination, ii)volumetric determination (dipon as sequestering titration agent), iii)capillary zone electrophoresis (CZE) determination. For kinetic determination of copper, the effect of interfering ions also forming complexes with dipon (Zn2+, Cd2+, Pb2+, Mn2+, Ca2+, Ni2+, Co2+, Mg2+) was studied. The high selectivity of copper determination was detected in case of low excess of interfering ions. Since a decrease of sensitivity was observed in real samples (alloys, mineral water) with high excess of interfering ions, the standard addition method was used here. The linear calibration curve has a dynamic range (5-250)*10-6 mol.l-1 (0.3-16 ppm) and detection limit of the method is 5*10-6 mol.l-1 (0.3 ppm). Microtitration method with spectrophotometric indication of equivalence point was developed for copper determination in high content copper alloys. Accuracy of the copper assay determined by volumetry was lower than 5% for samples of different composition alloys. The advantage of proposed method is that it is not necessary to use masking agents for the other metal ions as in case of other chelatometric titrations. Dipon was also used as selective agent for CZE copper determination in biological samples (human serum). Because of complicated matrix in such sample, the detection limit was 300 times higher than that one for aqueous solutions, therefore proposed method can be only used for determination of relatively high concentration of labile copper in biological samples as consequence of Wilson disease or copper intoxication.

Links

GA203/02/0493, research and development project

Name: Bifunkční cheláty. Syntéza a komplexotvorné vlastnosti

Investor: Czech Science Foundation, Bifunctional chelates. Synthesis and complexing properties

GA203/03/0168, research and development project

Name: Kineticky inertní komplexy iontů přechodných kovů a lanthanoidů. Design, syntéza a kinetická studia

MSM 143100011, plan (intention)

Name: Struktura a vazebné poměry, vlastnosti a analýza syntetických a přírodních molekulových ansamblů

Investor: Ministry of Education, Youth and Sports of the CR, Structure and character of bonding, properties and analysis of synthetic and natural molecular ensembles

Citovat

SVOBODOVÁ, Ivona, Přemysl LUBAL, Jiří MALEČEK, Jan KOTEK, Petr HERMANN, Josef HAVEL and Ivan LUKEŠ. Analytical Aplication of Dipon Ligand. In Book of Abstracts of XXVIII International Symposium on Macrocyclic Chemistry, Gdansk, Poland, July 13-18 2003. Gdansk: Gdansk University of Technology, 2003, p. P117, 1 pp. ISBN 83-914495-6-4.

@inproceedings{555453,
   author = {Svobodová, Ivona and Lubal, Přemysl and Maleček, Jiří and Kotek, Jan and Hermann, Petr and Havel, Josef and Lukeš, Ivan},
   address = {Gdansk},
   booktitle = {Book of Abstracts of XXVIII International Symposium on Macrocyclic Chemistry, Gdansk, Poland, July 13-18 2003},
   keywords = {1;4;8;11-tetraazacyclotetradecane-1;8-bis(methylphosphonic) acid; kinetic determination; volumetric determination; capillary zone electrophoresis determination},
   language = {eng},
   location = {Gdansk},
   isbn = {83-914495-6-4},
   pages = {P117},
   publisher = {Gdansk University of Technology},
   title = {Analytical Aplication of Dipon Ligand},
   year = {2003}
}

TY  - JOUR
ID  - 555453
AU  - Svobodová, Ivona - Lubal, Přemysl - Maleček, Jiří - Kotek, Jan - Hermann, Petr - Havel, Josef - Lukeš, Ivan
PY  - 2003
TI  - Analytical Aplication of Dipon Ligand
PB  - Gdansk University of Technology
CY  - Gdansk
SN  - 8391449564
KW  - 1;4;8;11-tetraazacyclotetradecane-1;8-bis(methylphosphonic) acid
KW  - kinetic determination
KW  - volumetric determination
KW  - capillary zone electrophoresis determination
N2  - Complexation reactions of macrocyclic ligands are widely utilized in analytical chemistry. Such ligands show high ion selectivity or catalytic activity of their complexes on chemical reactions. They can be applied for determination of inorganic as well as organic cations, anions and neutral compounds. In this work, the possible applications of macrocyclic ligand 1,4,8,11-tetraazacyclotetradecane-1,8-bis(methylphosphonic) acid, (dipon) in analytical chemistry were examined. The ligand exhibits extraordinary thermodynamic and kinetic stability of copper(II) complex in comparison to other metal ions. Three possibilities of utilization of dipon for copper analysis were proposed: i)kinetic determination, ii)volumetric determination (dipon as sequestering titration agent), iii)capillary zone electrophoresis (CZE) determination. For kinetic determination of copper, the effect of interfering ions also forming complexes with dipon (Zn2+, Cd2+, Pb2+, Mn2+, Ca2+, Ni2+, Co2+, Mg2+) was studied. The high selectivity of copper determination was detected in case of low excess of interfering ions. Since a decrease of sensitivity was observed in real samples (alloys, mineral water) with high excess of interfering ions, the standard addition method was used here. The linear calibration curve has a dynamic range (5-250)*10-6 mol.l-1 (0.3-16 ppm) and detection limit of the method is 5*10-6 mol.l-1 (0.3 ppm). Microtitration method with spectrophotometric indication of equivalence point was developed for copper determination in high content copper alloys. Accuracy of the copper assay determined by volumetry was lower than 5% for samples of different composition alloys. The advantage of proposed method is that it is not necessary to use masking agents for the other metal ions as in case of other chelatometric titrations. Dipon was also used as selective agent for CZE copper determination in biological samples (human serum). Because of complicated matrix in such sample, the detection limit was 300 times higher than that one for aqueous solutions, therefore proposed method can be only used for determination of relatively high concentration of labile copper in biological samples as consequence of Wilson disease or copper intoxication.
ER  -

SVOBODOVÁ, Ivona, Přemysl LUBAL, Jiří MALEČEK, Jan KOTEK, Petr HERMANN, Josef HAVEL and Ivan LUKEŠ. Analytical Aplication of Dipon Ligand. In \textit{Book of Abstracts of XXVIII International Symposium on Macrocyclic Chemistry, Gdansk, Poland, July 13-18 2003}. Gdansk: Gdansk University of Technology, 2003, p.~P117, 1 pp. ISBN~83-914495-6-4.

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