Kinetic Complexation and Decomplexation Study of
1,8-bis(methylphosphonic) Derivatives with Some Metal Ions

D 2003

Kinetic Complexation and Decomplexation Study of 1,8-bis(methylphosphonic) Derivatives with Some Metal Ions

SVOBODOVÁ, Ivona, Přemysl LUBAL, Jan KOTEK, Petr HERMANN, Josef HAVEL et. al.

Basic information

Original name

Kinetic Complexation and Decomplexation Study of 1,8-bis(methylphosphonic) Derivatives with Some Metal Ions

Authors

SVOBODOVÁ, Ivona (203 Czech Republic, guarantor), Přemysl LUBAL (203 Czech Republic), Jan KOTEK (203 Czech Republic), Petr HERMANN (203 Czech Republic), Josef HAVEL (203 Czech Republic) and Ivan LUKEŠ (203 Czech Republic)

Edition

Gdansk, Book of Abstracts of XXVIII International Symposium on Macrocyclic Chemistry, Gdansk, Poland, July 13-18 2003, p. P118, 1 pp. 2003

Publisher

Gdansk University of Technology

Other information

Language

English

Type of outcome

Stať ve sborníku

Field of Study

10406 Analytical chemistry

Country of publisher

Poland

Confidentiality degree

není předmětem státního či obchodního tajemství

RIV identification code

RIV/00216224:14310/03:00008744

Organization unit

Faculty of Science

ISBN

83-914495-6-4

Keywords in English

1;8-BIS(METHYLPHOSPHONIC) CYCLAM DERIVATIVES; copper(II) complexes; thermodynamics; kinetics; PET;

Abstract

V originále

Macrocyclic ligands are used as bifunctional chelating agents in nuclear medicine, e. g. in radioisotope diagnostics (64Cu - Beta+ emitter) or in tumor radiotherapy (67Cu - Beta- emitter). For possible medical applications, it is necessary to know thermodynamic and kinetic properties (rate constants of formation and dissociation) of copper and biometal complexes under experimental conditions similar to body fluids. In this work, the formation and dissociation kinetics of complexes of transitional metal ions with ligands, 1,4,8,11-tetraazacyclotetradecane-1,8-bis(methylphosphonic) acid (dipon, H4L1) and 4,11-dimethyl-1,4,8,11-tetraazacyclotetradecane-1,8-bis(methylphosphonic) acid (dimeMe2dipon, H4L2)was studied. The ligands form stable complexes with transitional metal ions Cu2+, Zn2+, Cd2+, Pb2+, Ca2+, Mg2+, Ni2+, Co2+. Formation (kf) and dissociation (kd) constants of Cu2+, Zn2+ and Cd2+ complexes with ligands dipon and dimeMe2dipon were measured under experimental conditions (t = 25oC, I = 0,1 mol.l-1). The formation and dissociation of metal complex of both ligands were explained and reaction mechanisms were postulated. The highest stability (kinetic as well as thermodynamic) is demonstrated by both ligands for copper(II), while the complex is already formed in solutions with pH lower than 2. The formation rate of copper complex of both ligands complex is 1000 times higher than complexes with the other studied ions. The dissociation of this complex takes place at lower pH than complexes with the other studied ions.

Links

GA203/02/0493, research and development project

Name: Bifunkční cheláty. Syntéza a komplexotvorné vlastnosti

Investor: Czech Science Foundation, Bifunctional chelates. Synthesis and complexing properties

GA203/03/0168, research and development project

Name: Kineticky inertní komplexy iontů přechodných kovů a lanthanoidů. Design, syntéza a kinetická studia

MSM 143100011, plan (intention)

Name: Struktura a vazebné poměry, vlastnosti a analýza syntetických a přírodních molekulových ansamblů

Investor: Ministry of Education, Youth and Sports of the CR, Structure and character of bonding, properties and analysis of synthetic and natural molecular ensembles

Citovat

SVOBODOVÁ, Ivona, Přemysl LUBAL, Jan KOTEK, Petr HERMANN, Josef HAVEL and Ivan LUKEŠ. Kinetic Complexation and Decomplexation Study of 1,8-bis(methylphosphonic) Derivatives with Some Metal Ions. In Book of Abstracts of XXVIII International Symposium on Macrocyclic Chemistry, Gdansk, Poland, July 13-18 2003. Gdansk: Gdansk University of Technology, 2003, p. P118, 1 pp. ISBN 83-914495-6-4.

@inproceedings{555459,
   author = {Svobodová, Ivona and Lubal, Přemysl and Kotek, Jan and Hermann, Petr and Havel, Josef and Lukeš, Ivan},
   address = {Gdansk},
   booktitle = {Book of Abstracts of XXVIII International Symposium on Macrocyclic Chemistry, Gdansk, Poland, July 13-18 2003},
   keywords = {1;8-BIS(METHYLPHOSPHONIC) CYCLAM DERIVATIVES; copper(II) complexes; thermodynamics; kinetics; PET;},
   language = {eng},
   location = {Gdansk},
   isbn = {83-914495-6-4},
   pages = {P118},
   publisher = {Gdansk University of Technology},
   title = {Kinetic Complexation and Decomplexation Study of 1,8-bis(methylphosphonic) Derivatives with Some Metal Ions},
   year = {2003}
}

TY  - JOUR
ID  - 555459
AU  - Svobodová, Ivona - Lubal, Přemysl - Kotek, Jan - Hermann, Petr - Havel, Josef - Lukeš, Ivan
PY  - 2003
TI  - Kinetic Complexation and Decomplexation Study of 1,8-bis(methylphosphonic) Derivatives with Some Metal Ions
PB  - Gdansk University of Technology
CY  - Gdansk
SN  - 8391449564
KW  - 1;8-BIS(METHYLPHOSPHONIC) CYCLAM DERIVATIVES
KW  - copper(II) complexes
KW  - thermodynamics
KW  - kinetics
KW  - PET;
N2  - Macrocyclic ligands are used as bifunctional chelating agents in nuclear medicine, e. g. in radioisotope diagnostics (64Cu - Beta+ emitter) or in tumor radiotherapy (67Cu - Beta- emitter). For possible medical applications, it is necessary to know thermodynamic and kinetic properties (rate constants of formation and dissociation) of copper and biometal complexes under experimental conditions similar to body fluids. In this work, the formation and dissociation kinetics of complexes of transitional metal ions with ligands, 1,4,8,11-tetraazacyclotetradecane-1,8-bis(methylphosphonic) acid (dipon, H4L1) and 4,11-dimethyl-1,4,8,11-tetraazacyclotetradecane-1,8-bis(methylphosphonic) acid (dimeMe2dipon, H4L2)was studied. The ligands form stable complexes with transitional metal ions Cu2+, Zn2+, Cd2+, Pb2+, Ca2+, Mg2+, Ni2+, Co2+. Formation (kf) and dissociation (kd) constants of Cu2+, Zn2+ and Cd2+ complexes with ligands dipon and dimeMe2dipon were measured under experimental conditions (t = 25oC, I = 0,1 mol.l-1). The formation and dissociation of metal complex of both ligands were explained and reaction mechanisms were postulated. The highest stability (kinetic as well as thermodynamic) is demonstrated by both ligands for copper(II), while the complex is already formed in solutions with pH lower than 2. The formation rate of copper complex of both ligands complex is 1000 times higher than complexes with the other studied ions. The dissociation of this complex takes place at lower pH than complexes with the other studied ions.
ER  -

SVOBODOVÁ, Ivona, Přemysl LUBAL, Jan KOTEK, Petr HERMANN, Josef HAVEL and Ivan LUKEŠ. Kinetic Complexation and Decomplexation Study of 1,8-bis(methylphosphonic) Derivatives with Some Metal Ions. In \textit{Book of Abstracts of XXVIII International Symposium on Macrocyclic Chemistry, Gdansk, Poland, July 13-18 2003}. Gdansk: Gdansk University of Technology, 2003, p.~P118, 1 pp. ISBN~83-914495-6-4.

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