Spectroscopic Characterization of New Eu(III)/DOTA Analogue
Complexes as potential MRI Agents

D 2003

Spectroscopic Characterization of New Eu(III)/DOTA Analogue Complexes as potential MRI Agents

TÁBORSKÝ, Petr, Přemysl LUBAL, Josef HAVEL, Petr HERMANN, Ivan LUKEŠ et. al.

Basic information

Original name

Spectroscopic Characterization of New Eu(III)/DOTA Analogue Complexes as potential MRI Agents

Authors

TÁBORSKÝ, Petr (203 Czech Republic, guarantor), Přemysl LUBAL (203 Czech Republic), Josef HAVEL (203 Czech Republic), Petr HERMANN (203 Czech Republic), Ivan LUKEŠ (203 Czech Republic), Zbigniew HNATEJKO (616 Poland) and Stefan LIS (616 Poland)

Edition

Poznan, Abstract Book of Conference "TOWARDS MOLECULAR ELECTRONICS" (Central European Conference on Advanced Materials and Nanotechnology), Srem, Poland, June 23-28, 2003. p. 105-105, 2003

Publisher

Adam Mickiewicz University

Other information

Language

English

Type of outcome

Stať ve sborníku

Field of Study

10406 Analytical chemistry

Country of publisher

Poland

Confidentiality degree

není předmětem státního či obchodního tajemství

RIV identification code

RIV/00216224:14310/03:00008746

Organization unit

Faculty of Science

Keywords in English

MRI; macrocyclic ligands; europium(III); lumininiscence study; luminiscent probes

Abstract

V originále

Ln(III) complexes of DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate) and their analogues are used for their high thermodynamic stability, kinetic inertness and other properties as MRI or luminescent probes in medicine. New analogues of DOTA were prepared by substitution of one acetic group by pendant groups containing phosphonic group. The formation kinetics between Eu(III) and recently synthesized ligands were studied under experimental conditions (t = 25 oC, I = 0.1 mol.l-1, pH = 4-6) by means of UV/VIS absorption spectroscopy and two steps were observed: Eu3+ + HxL <=> (x-y)H+ + Eu(HyL) --> Eu(L) + yH+ The first step - the coordination of Eu(III) ion by pendant groups is very fast. In the second step, the transformation of an intermediate to the final complex in which Eu(III) ion is coordinated by four pendant groups and four nitrogen donor atoms of the cyclen ring, takes place. This step is very slow and it is proportional to OH- ion concentration. The estimates of protonation constants of the intermediates and rate constants of the second step were determined. A luminescence life time studies revealed that the number of water molecules coordinated to the Eu(III) ion in Eu(L) complexes at pH = 7.4 is about one (q=1) what proves that the Eu(III) ion is also bound by phosphonic group.

Links

GA203/02/0493, research and development project

Name: Bifunkční cheláty. Syntéza a komplexotvorné vlastnosti

Investor: Czech Science Foundation, Bifunctional chelates. Synthesis and complexing properties

GA203/03/0168, research and development project

Name: Kineticky inertní komplexy iontů přechodných kovů a lanthanoidů. Design, syntéza a kinetická studia

MSM 143100011, plan (intention)

Name: Struktura a vazebné poměry, vlastnosti a analýza syntetických a přírodních molekulových ansamblů

Investor: Ministry of Education, Youth and Sports of the CR, Structure and character of bonding, properties and analysis of synthetic and natural molecular ensembles

Citovat

TÁBORSKÝ, Petr, Přemysl LUBAL, Josef HAVEL, Petr HERMANN, Ivan LUKEŠ, Zbigniew HNATEJKO and Stefan LIS. Spectroscopic Characterization of New Eu(III)/DOTA Analogue Complexes as potential MRI Agents. In Abstract Book of Conference "TOWARDS MOLECULAR ELECTRONICS" (Central European Conference on Advanced Materials and Nanotechnology), Srem, Poland, June 23-28, 2003. Poznan: Adam Mickiewicz University, 2003, p. 105.

@inproceedings{555467,
   author = {Táborský, Petr and Lubal, Přemysl and Havel, Josef and Hermann, Petr and Lukeš, Ivan and Hnatejko, Zbigniew and Lis, Stefan},
   address = {Poznan},
   booktitle = {Abstract Book of Conference "TOWARDS MOLECULAR ELECTRONICS" (Central European Conference on Advanced Materials and Nanotechnology), Srem, Poland, June 23-28, 2003.},
   keywords = {MRI; macrocyclic ligands; europium(III); lumininiscence study; luminiscent probes},
   language = {eng},
   location = {Poznan},
   pages = {105-105},
   publisher = {Adam Mickiewicz University},
   title = {Spectroscopic Characterization of New Eu(III)/DOTA Analogue Complexes as potential MRI Agents},
   year = {2003}
}

TY  - JOUR
ID  - 555467
AU  - Táborský, Petr - Lubal, Přemysl - Havel, Josef - Hermann, Petr - Lukeš, Ivan - Hnatejko, Zbigniew - Lis, Stefan
PY  - 2003
TI  - Spectroscopic Characterization of New Eu(III)/DOTA Analogue Complexes as potential MRI Agents
PB  - Adam Mickiewicz University
CY  - Poznan
KW  - MRI
KW  - macrocyclic ligands
KW  - europium(III)
KW  - lumininiscence study
KW  - luminiscent probes
N2  - Ln(III) complexes of DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate) and their analogues are used for their high thermodynamic stability, kinetic inertness and other properties as MRI or luminescent probes in medicine. New analogues of DOTA were prepared by substitution of one acetic group by pendant groups containing phosphonic group. The formation kinetics between Eu(III) and recently synthesized ligands were studied under experimental conditions (t = 25 oC, I = 0.1 mol.l-1, pH = 4-6) by means of UV/VIS absorption spectroscopy and two steps were observed: Eu3+ + HxL <=> (x-y)H+ + Eu(HyL) --> Eu(L) + yH+ The first step - the coordination of Eu(III) ion by pendant groups is very fast. In the second step, the transformation of an intermediate to the final complex in which Eu(III) ion is coordinated by four pendant groups and four nitrogen donor atoms of the cyclen ring, takes place. This step is very slow and it is proportional to OH- ion concentration. The estimates of protonation constants of the intermediates and rate constants of the second step were determined. A luminescence life time studies revealed that the number of water molecules coordinated to the Eu(III) ion in Eu(L) complexes at pH = 7.4 is about one (q=1) what proves that the Eu(III) ion is also bound by phosphonic group.
ER  -

TÁBORSKÝ, Petr, Přemysl LUBAL, Josef HAVEL, Petr HERMANN, Ivan LUKEŠ, Zbigniew HNATEJKO and Stefan LIS. Spectroscopic Characterization of New Eu(III)/DOTA Analogue Complexes as potential MRI Agents. In \textit{Abstract Book of Conference ''TOWARDS MOLECULAR ELECTRONICS'' (Central European Conference on Advanced Materials and Nanotechnology), Srem, Poland, June 23-28, 2003.}. Poznan: Adam Mickiewicz University, 2003, p.~105.

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