Detailed Information on Publication Record
2003
Spectroscopic Characterization of New Eu(III)/DOTA Analogue Complexes as potential MRI Agents
TÁBORSKÝ, Petr, Přemysl LUBAL, Josef HAVEL, Petr HERMANN, Ivan LUKEŠ et. al.Basic information
Original name
Spectroscopic Characterization of New Eu(III)/DOTA Analogue Complexes as potential MRI Agents
Authors
TÁBORSKÝ, Petr (203 Czech Republic, guarantor), Přemysl LUBAL (203 Czech Republic), Josef HAVEL (203 Czech Republic), Petr HERMANN (203 Czech Republic), Ivan LUKEŠ (203 Czech Republic), Zbigniew HNATEJKO (616 Poland) and Stefan LIS (616 Poland)
Edition
Poznan, Abstract Book of Conference "TOWARDS MOLECULAR ELECTRONICS" (Central European Conference on Advanced Materials and Nanotechnology), Srem, Poland, June 23-28, 2003. p. 105-105, 2003
Publisher
Adam Mickiewicz University
Other information
Language
English
Type of outcome
Stať ve sborníku
Field of Study
10406 Analytical chemistry
Country of publisher
Poland
Confidentiality degree
není předmětem státního či obchodního tajemství
RIV identification code
RIV/00216224:14310/03:00008746
Organization unit
Faculty of Science
Keywords in English
MRI; macrocyclic ligands; europium(III); lumininiscence study; luminiscent probes
Změněno: 31/5/2004 17:02, prof. RNDr. Přemysl Lubal, Ph.D.
Abstract
V originále
Ln(III) complexes of DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate) and their analogues are used for their high thermodynamic stability, kinetic inertness and other properties as MRI or luminescent probes in medicine. New analogues of DOTA were prepared by substitution of one acetic group by pendant groups containing phosphonic group. The formation kinetics between Eu(III) and recently synthesized ligands were studied under experimental conditions (t = 25 oC, I = 0.1 mol.l-1, pH = 4-6) by means of UV/VIS absorption spectroscopy and two steps were observed: Eu3+ + HxL <=> (x-y)H+ + Eu(HyL) --> Eu(L) + yH+ The first step - the coordination of Eu(III) ion by pendant groups is very fast. In the second step, the transformation of an intermediate to the final complex in which Eu(III) ion is coordinated by four pendant groups and four nitrogen donor atoms of the cyclen ring, takes place. This step is very slow and it is proportional to OH- ion concentration. The estimates of protonation constants of the intermediates and rate constants of the second step were determined. A luminescence life time studies revealed that the number of water molecules coordinated to the Eu(III) ion in Eu(L) complexes at pH = 7.4 is about one (q=1) what proves that the Eu(III) ion is also bound by phosphonic group.
Links
GA203/02/0493, research and development project |
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GA203/03/0168, research and development project |
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MSM 143100011, plan (intention) |
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