KINETIC STUDIES OF COMPLEXATION AND DECOMPLEXATION OF
BIS(PHOSPHONIC ACID) CYCLAM DERIVATIVES WITH COPPER(II) ION

D 2004

KINETIC STUDIES OF COMPLEXATION AND DECOMPLEXATION OF BIS(PHOSPHONIC ACID) CYCLAM DERIVATIVES WITH COPPER(II) ION

SVOBODOVÁ, Ivona, Michaela MUDROVÁ, Přemysl LUBAL, Jan KOTEK, Petr HERMANN et. al.

Basic information

Original name

KINETIC STUDIES OF COMPLEXATION AND DECOMPLEXATION OF BIS(PHOSPHONIC ACID) CYCLAM DERIVATIVES WITH COPPER(II) ION

Authors

SVOBODOVÁ, Ivona (203 Czech Republic), Michaela MUDROVÁ (203 Czech Republic), Přemysl LUBAL (203 Czech Republic, guarantor), Jan KOTEK (203 Czech Republic), Petr HERMANN (203 Czech Republic), Josef HAVEL (203 Czech Republic) and Ivan LUKEŠ (203 Czech Republic)

Edition

Athens, Book of Abstracts of Inorganic Reaction Mechanisms Meeting 2003, January 8-10, 2004, Athens, Greece, p. 10-10, 2004

Publisher

National and Kapodistrian University of Athens

Other information

Language

English

Type of outcome

Stať ve sborníku

Field of Study

10406 Analytical chemistry

Country of publisher

Greece

Confidentiality degree

není předmětem státního či obchodního tajemství

Organization unit

Faculty of Science

Keywords in English

BIS(PHOSPHONIC ACID) CYCLAM DERIVATIVES; copper(II) complexes; thermodynamics; kinetics

Abstract

V originále

Complexes of Cu(II) with macrocyclic ligands are utilized as bifunctional chelating agents in nuclear medicine, e.g. in radioisotope diagnostics (64Cu) or in tumor radiotherapy (67Cu). There is necessity to know thermodynamic and kinetic properties (formation and dissociation rate constants) of copper and other biometal ion complexes under experimental conditions similar to body fluids for possible medical application in vivo. In this work, the formation kinetics of copper(II) complexes of macrocyclic ligands with phosphonic acid pendant arms was studied (dipon, L1, Me2dipon, L2, dipon-diester, L3) (t = 25 oC, I = 0.1 M). The reactivity decreases in order L1 > L2 > L3. The copper(II) complex of L1 ligand can be found in two isomeric forms. They differ in the number of bound donor atoms and cyclam skeleton arrangement. The mechanism of isomerisation reaction was studied in different media (aqueous ammonia, water) by means of different experimental techniques and catalysis of reaction by ammonia was observed. The dissociation kinetics of copper(II) complexes of L1 and L2 macrocyclic ligands was investigated under extreme experimental conditions (t = 25-65 oC, I = 5 M (Na,H)ClO4). The acid-assisted dissociation of complexes is faster for [Cu(H2L2)] than for [Cu(H2L1)] compounds. In case [Cu(H2L1)], both isomeric species demonstrate a high kinetic inertness in presence of 5 M perchloric acid (t = 25 oC, Tau1/2 = 20 min and 6.7 months for penta- and hexacoordinated isomers, respectively).

Links

GA203/02/0493, research and development project

Name: Bifunkční cheláty. Syntéza a komplexotvorné vlastnosti

Investor: Czech Science Foundation, Bifunctional chelates. Synthesis and complexing properties

GA203/03/0168, research and development project

Name: Kineticky inertní komplexy iontů přechodných kovů a lanthanoidů. Design, syntéza a kinetická studia

MSM 143100011, plan (intention)

Name: Struktura a vazebné poměry, vlastnosti a analýza syntetických a přírodních molekulových ansamblů

Investor: Ministry of Education, Youth and Sports of the CR, Structure and character of bonding, properties and analysis of synthetic and natural molecular ensembles

Citovat

SVOBODOVÁ, Ivona, Michaela MUDROVÁ, Přemysl LUBAL, Jan KOTEK, Petr HERMANN, Josef HAVEL and Ivan LUKEŠ. KINETIC STUDIES OF COMPLEXATION AND DECOMPLEXATION OF BIS(PHOSPHONIC ACID) CYCLAM DERIVATIVES WITH COPPER(II) ION. In Book of Abstracts of Inorganic Reaction Mechanisms Meeting 2003, January 8-10, 2004, Athens, Greece. Athens: National and Kapodistrian University of Athens, 2004, p. 10.

@inproceedings{555469,
   author = {Svobodová, Ivona and Mudrová, Michaela and Lubal, Přemysl and Kotek, Jan and Hermann, Petr and Havel, Josef and Lukeš, Ivan},
   address = {Athens},
   booktitle = {Book of Abstracts of Inorganic Reaction Mechanisms Meeting 2003, January 8-10, 2004, Athens, Greece},
   keywords = {BIS(PHOSPHONIC ACID) CYCLAM DERIVATIVES; copper(II) complexes; thermodynamics; kinetics},
   language = {eng},
   location = {Athens},
   pages = {10-10},
   publisher = {National and Kapodistrian University of Athens},
   title = {KINETIC STUDIES OF COMPLEXATION AND DECOMPLEXATION OF BIS(PHOSPHONIC ACID) CYCLAM DERIVATIVES WITH COPPER(II) ION},
   year = {2004}
}

TY  - JOUR
ID  - 555469
AU  - Svobodová, Ivona - Mudrová, Michaela - Lubal, Přemysl - Kotek, Jan - Hermann, Petr - Havel, Josef - Lukeš, Ivan
PY  - 2004
TI  - KINETIC STUDIES OF COMPLEXATION AND DECOMPLEXATION OF BIS(PHOSPHONIC ACID) CYCLAM DERIVATIVES WITH COPPER(II) ION
PB  - National and Kapodistrian University of Athens
CY  - Athens
KW  - BIS(PHOSPHONIC ACID) CYCLAM DERIVATIVES
KW  - copper(II) complexes
KW  - thermodynamics
KW  - kinetics
N2  - Complexes of Cu(II) with macrocyclic ligands are utilized as bifunctional chelating agents in nuclear medicine, e.g. in radioisotope diagnostics (64Cu) or in tumor radiotherapy (67Cu). There is necessity to know thermodynamic and kinetic properties (formation and dissociation rate constants) of copper and other biometal ion complexes under experimental conditions similar to body fluids for possible medical application in vivo. In this work, the formation kinetics of copper(II) complexes of macrocyclic ligands with phosphonic acid pendant arms was studied (dipon, L1, Me2dipon, L2, dipon-diester, L3) (t = 25 oC, I = 0.1 M). The reactivity decreases in order L1 > L2 > L3. The copper(II) complex of L1 ligand can be found in two isomeric forms. They differ in the number of bound donor atoms and cyclam skeleton arrangement. The mechanism of isomerisation reaction was studied in different media (aqueous ammonia, water) by means of different experimental techniques and catalysis of reaction by ammonia was observed. The dissociation kinetics of copper(II) complexes of L1 and L2 macrocyclic ligands was investigated under extreme experimental conditions (t = 25-65 oC, I = 5 M (Na,H)ClO4). The acid-assisted dissociation of complexes is faster for [Cu(H2L2)] than for [Cu(H2L1)] compounds. In case [Cu(H2L1)], both isomeric species demonstrate a high kinetic inertness in presence of 5 M perchloric acid (t = 25 oC, Tau1/2 = 20 min and 6.7 months for penta- and hexacoordinated isomers, respectively).
ER  -

SVOBODOVÁ, Ivona, Michaela MUDROVÁ, Přemysl LUBAL, Jan KOTEK, Petr HERMANN, Josef HAVEL and Ivan LUKEŠ. KINETIC STUDIES OF COMPLEXATION AND DECOMPLEXATION OF BIS(PHOSPHONIC ACID) CYCLAM DERIVATIVES WITH COPPER(II) ION. In \textit{Book of Abstracts of Inorganic Reaction Mechanisms Meeting 2003, January 8-10, 2004, Athens, Greece}. Athens: National and Kapodistrian University of Athens, 2004, p.~10.

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