HOUŠTĚK, Josef, Petr TVRDÍK, Stanislav PAVELKA and Marie BAUDYŠOVÁ. Low content of mitochondrial ATPase in brown adipose tissue is the result of post-transcriptional regulation. FEBS Letters [IF=3.479 (1990); SCI #cit.<22>]. 1991, vol. 294, No 3, p. 191-194. ISSN 0014-5793.
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Basic information
Original name Low content of mitochondrial ATPase in brown adipose tissue is the result of post-transcriptional regulation
Authors HOUŠTĚK, Josef, Petr TVRDÍK, Stanislav PAVELKA and Marie BAUDYŠOVÁ.
Edition FEBS Letters [IF=3.479 (1990); SCI #cit.<22>], 1991, 0014-5793.
Other information
Original language English
Type of outcome Article in a journal
Field of Study Genetics and molecular biology
Country of publisher Netherlands
Confidentiality degree is not subject to a state or trade secret
Organization unit Faculty of Science
Keywords in English ATPase; brown adipose tissue; cytochrome oxidase; mitochondrion; nuclear gene; transcription
Tags ATPase, brown adipose tissue, cytochrome oxidase, mitochondrion, nuclear gene, Transcription
Tags International impact, Reviewed
Changed by Changed by: doc. RNDr. Stanislav Pavelka, CSc., učo 313. Changed: 4/1/2009 07:59.
Abstract
The mRNA levels of ATPase beta, ATPase 6, cytochrome oxidase (COX) VIb and COX I subunits were found to be 2.4-13.8-fold higher in brown adipose tissue (BAT) than in heart, skeletal muscle, brain and liver of mice. The comparison with tissue contents of ATPase and COX revealed that the selective, 5-11-fold reduction of ATPase in BAT is not caused by decreased transcription of ATPase genes. The results indicate that the biosynthesis of mitochondrial ATPase in BAT is post-transcriptionally regulated.
Links
IA51146, research and development projectName: Regulace biosyntézy energii-transdukujících proteinů savčích mitochondrií in situ a v buněčné kultuře
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