PAVELKA, Stanislav, Jana HEŘMANSKÁ, Marie BAUDYŠOVÁ and Josef HOUŠTĚK. Adrenergic control of induction of type II iodothyronine 5'-deiodinase activity in cultured brown adipocytes. Biochemical Journal [IF=3.659 (1992); SCI #cit.<9>]. 1993, vol. 292, 3,, p. 303-308. ISSN 0264-6021.
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Basic information
Original name Adrenergic control of induction of type II iodothyronine 5'-deiodinase activity in cultured brown adipocytes
Authors PAVELKA, Stanislav (203 Czech Republic, guarantor), Jana HEŘMANSKÁ (203 Czech Republic), Marie BAUDYŠOVÁ (203 Czech Republic) and Josef HOUŠTĚK (203 Czech Republic).
Edition Biochemical Journal [IF=3.659 (1992); SCI #cit.<9>], 1993, 0264-6021.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 10600 1.6 Biological sciences
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
RIV identification code RIV/00216224:14330/93:00011185
Organization unit Faculty of Informatics
Keywords in English Adrenergic agonists and antagonists; cultured brown adipocytes; iodothyronine deiodinase
Tags Adrenergic agonists and antagonists, cultured brown adipocytes, iodothyronine deiodinase
Tags International impact, Reviewed
Changed by Changed by: doc. RNDr. Stanislav Pavelka, CSc., učo 313. Changed: 4/1/2009 11:29.
Abstract
Iodothyronine 5'-deiodinase (5'D) of mouse brown adipocytes differentiated in cell culture was characterized in detail with respect to the adrenergic control of its biosynthesis. The stimulation of 5'D required mRNA and protein synthesis and was dependent on the stage of differentiation of the cells. Contrary to previous observations in vivo, stimulation of 5'D in cultured brown fat-cells involves elevated cyclic AMP levels and is mediated predominantly via beta-receptors, particularly via the so-called beta3-adrenoceptors.
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IA51146, research and development projectName: Regulace biosyntézy energii-transdukujících proteinů savčích mitochondrií in situ a v buněčné kultuře
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