ESFANDIARI, Ali, Claire GAGELIN, Jean-Michel GAVARET, Stanislav PAVELKA, Ana-Maria LENNON, Michel PIERRE and Francoise COURTIN. Induction of type III-deiodinase activity in astroglial cells by retinoids. Glia [IF=5.096 (1993); SCI #cit.<35>]. 1994, vol. 11, 6,, p. 255-261. ISSN 0894-1491.
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Basic information
Original name Induction of type III-deiodinase activity in astroglial cells by retinoids
Authors ESFANDIARI, Ali (364 Islamic Republic of Iran), Claire GAGELIN (250 France), Jean-Michel GAVARET (250 France), Stanislav PAVELKA (203 Czech Republic, guarantor), Ana-Maria LENNON (250 France), Michel PIERRE (250 France) and Francoise COURTIN (250 France).
Edition Glia [IF=5.096 (1993); SCI #cit.<35>], 1994, 0894-1491.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30000 3. Medical and Health Sciences
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
RIV identification code RIV/00216224:14310/94:00011186
Organization unit Faculty of Science
UT WoS A1994NU31200005
Keywords in English Brain; cultured astrocytes; deiodinase; retinoic acid; thyroid hormones
Tags brain, cultured astrocytes, deiodinase, retinoic acid, thyroid hormones
Tags International impact, Reviewed
Changed by Changed by: doc. RNDr. Stanislav Pavelka, CSc., učo 313. Changed: 4/1/2009 12:19.
Abstract
Thyroid hormones and retinoic acid (RA) are important modulators of growth, development, and differentiation. The effects of retinoids on type III deiodinase (D-III) activity were examined in astroglial cells cultured in a chemically defined medium devoid of hormones and growth factors. Incubation of astroglial cells with 5 micromolar all-trans-RA caused up to 200-fold increase in D-III activity, which reached a plateau after 48 h. All-trans-RA (5 uM) had little or no effect on type II deiodinase, the enzyme which catalyzes the activation of thyroxine to 3,5,3'-triiodothyronine.
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IA51146, research and development projectName: Regulace biosyntézy energii-transdukujících proteinů savčích mitochondrií in situ a v buněčné kultuře
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