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@inproceedings{555974, author = {Tarabová, Bohuslava and Nováková, Marie and Bébarová, Markéta and Pásek, Michal and Matejovič, Peter and Lacinová, Lubica}, address = {Bratislava}, booktitle = {Membrane Channels, Transporters and Receptors}, edition = {1}, keywords = {haloperidol; patch clamp; rat cardiomyocytes; HEK 293 cells}, language = {eng}, location = {Bratislava}, pages = {54-54}, publisher = {Institute of Molecular Physiology and Genetics}, title = {Effect of haloperidol on voltage dependent cardiac ion channels}, year = {2004} }
TY - JOUR ID - 555974 AU - Tarabová, Bohuslava - Nováková, Marie - Bébarová, Markéta - Pásek, Michal - Matejovič, Peter - Lacinová, Lubica PY - 2004 TI - Effect of haloperidol on voltage dependent cardiac ion channels PB - Institute of Molecular Physiology and Genetics CY - Bratislava KW - haloperidol KW - patch clamp KW - rat cardiomyocytes KW - HEK 293 cells N2 - Haloperidol is a neuroleptic agent effective in treatment of various psychiatric diseases. Cardiac arrhythmias have been associated with this therapy. We have investigated effects of haloperidol on cardiac sodium, potassium and calcium channels using whole cell patch-clamp method. 10 microM concentration of haloperidol was tested. In cardiomyocytes isolated from adult rat ventricles, haloperidol inhibited 95% of sodium current (INa) activated by 40 ms voltage pulses from -75 mV to -20 mV. The block of the transient outward potassium current (Ito) and current at the end of the pulse (IK,end) were measured by 300 ms voltage pulses from -75 mV to +40 mV. Haloperidol caused 80% block of Ito and 37% block of IK,end. In all cases the block was reversible. Further, we have investigated CaV1.2 L-type calcium channel transiently expressed in HEK 293 cells. Haloperidol inhibited approximately 58% of inward current amplitude measured in peak of IV relation. The inhibition was reversible and voltage dependent. Increasing amplitude of depolarizing pulses increased strongly extent of current inhibition. ER -
TARABOVÁ, Bohuslava, Marie NOVÁKOVÁ, Markéta BÉBAROVÁ, Michal PÁSEK, Peter MATEJOVIČ and Lubica LACINOVÁ. Effect of haloperidol on voltage dependent cardiac ion channels. In \textit{Membrane Channels, Transporters and Receptors}. 1st ed. Bratislava: Institute of Molecular Physiology and Genetics, 2004, p.~54.
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