Cross-sensitization with morphine to methamphetamine effects on locomotion in mice

LANDA, Leoš, Karel ŠLAIS and Alexandra ŠULCOVÁ. Cross-sensitization with morphine to methamphetamine effects on locomotion in mice. Homeostasis in Health and Diseases. Milano, Italy: CIANS Homeostasis, 2004, vol. 43, No 1, p. 43-44. ISSN 0960-7560.

Basic information

Original name

Cross-sensitization with morphine to methamphetamine effects on locomotion in mice

Name in Czech

Zkřížená sensitizace morfinem k účinkům metamfetaminu na lokomoci u myší

Authors

LANDA, Leoš (203 Czech Republic, guarantor), Karel ŠLAIS (203 Czech Republic) and Alexandra ŠULCOVÁ (203 Czech Republic)

Edition

Homeostasis in Health and Diseases, Milano, Italy, CIANS Homeostasis, 2004, 0960-7560

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Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

RIV identification code

RIV/00216224:14110/04:00010237

Organization unit

Faculty of Medicine

Keywords in English

behavioural sensitization; methamphetamine; morphine; locomotor activity; mice

Tags

behavioural sensitization, locomotor activity, methamphetamine, mice, morphine

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Abstract

V originále

This study was aimed on development of cross-sensitization with morphine (MO) to methamphetamine (MET). Behavioural responses were measured in the "open field" test. Mice in two groups were pretreated for seven days either with MO at the dose 10 mg/kg/day or with MET at the dose of 2,5 mg/kg/day. On the day 8 all mice were given the "challenge dose" of MET 2.5 mg/kg to evaluate if a cross-sensitization developed. It has been shown that behavioural sensitization was present in both the group pretreated with MET and also in the group pretreated with MO.

In Czech

Premedikace morfinem sensitizuje k stimulačním účinkům metamfetaminu na lokomoci u myší.