LANDA, Leoš, Karel ŠLAIS and Alexandra ŠULCOVÁ. The impact of the cannabinoid CB2 receptor agonist JWH 015 on development of methamphetamine sensitization to locomotor/exploratory activity in mice. Homeostasis in Health and Diseases. Milano, Italy: CIANS Homeostasis, 2004, vol. 43, No 1, p. 39-41. ISSN 0960-7560.
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Basic information
Original name The impact of the cannabinoid CB2 receptor agonist JWH 015 on development of methamphetamine sensitization to locomotor/exploratory activity in mice
Name in Czech Vliv agonisty kanabinoidního receptoru CB2 JWH015 an rozvoj sensitizace k behaviorálnímu účinku metamfetaminu na lokomočně/pátrací aktivitu myší
Authors LANDA, Leoš (203 Czech Republic, guarantor), Karel ŠLAIS (203 Czech Republic) and Alexandra ŠULCOVÁ (203 Czech Republic).
Edition Homeostasis in Health and Diseases, Milano, Italy, CIANS Homeostasis, 2004, 0960-7560.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30104 Pharmacology and pharmacy
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
RIV identification code RIV/00216224:14110/04:00010238
Organization unit Faculty of Medicine
Keywords in English behavioural sensitization; methamphetamine; JWH-015; locomotor activity; mice
Tags behavioural sensitization, JWH-015, locomotor activity, methamphetamine, mice
Changed by Changed by: prof. MUDr. Alexandra Šulcová, CSc., učo 1937. Changed: 29/12/2004 14:34.
Abstract
The present study was designed to test a possible effect of selective agonist at cannabinoid CB2 receptor - JWH 015 (JWH) on behavioural sensitization to MET. Behavioural changes were measured in the open field test. MET and combined MET+JWH pretreatments were administered for 7 days to the mice at the doses of 2.5 mg/kg/day and 5 mg/kg/ day, respectively. On the day 8 all mice were given a "challenge dose" of MET 2.5 mg/kg to check a development of sensitization phenomenon. The sensitization to MET has not been altered in the case of use of JWH in the pretreatment.
Abstract (in Czech)
Rozvoj behaviorální sensitizace k metamfetaminovému účinku na lokomoci u myší není alterován premedikací agonistou CNB2 kanabinoidních receptorů JWH015.
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