The impact of the cannabinoid CB2 receptor agonist JWH 015 on development of methamphetamine sensitization to locomotor/exploratory activity in mice

LANDA, Leoš, Karel ŠLAIS and Alexandra ŠULCOVÁ. The impact of the cannabinoid CB2 receptor agonist JWH 015 on development of methamphetamine sensitization to locomotor/exploratory activity in mice. Homeostasis in Health and Diseases. Milano, Italy: CIANS Homeostasis, 2004, vol. 43, No 1, p. 39-41. ISSN 0960-7560.

Basic information

Original name

The impact of the cannabinoid CB2 receptor agonist JWH 015 on development of methamphetamine sensitization to locomotor/exploratory activity in mice

Name in Czech

Vliv agonisty kanabinoidního receptoru CB2 JWH015 an rozvoj sensitizace k behaviorálnímu účinku metamfetaminu na lokomočně/pátrací aktivitu myší

Authors

LANDA, Leoš (203 Czech Republic, guarantor), Karel ŠLAIS (203 Czech Republic) and Alexandra ŠULCOVÁ (203 Czech Republic)

Edition

Homeostasis in Health and Diseases, Milano, Italy, CIANS Homeostasis, 2004, 0960-7560

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Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

RIV identification code

RIV/00216224:14110/04:00010238

Organization unit

Faculty of Medicine

Keywords in English

behavioural sensitization; methamphetamine; JWH-015; locomotor activity; mice

Tags

behavioural sensitization, JWH-015, locomotor activity, methamphetamine, mice

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Abstract

V originále

The present study was designed to test a possible effect of selective agonist at cannabinoid CB2 receptor - JWH 015 (JWH) on behavioural sensitization to MET. Behavioural changes were measured in the open field test. MET and combined MET+JWH pretreatments were administered for 7 days to the mice at the doses of 2.5 mg/kg/day and 5 mg/kg/ day, respectively. On the day 8 all mice were given a "challenge dose" of MET 2.5 mg/kg to check a development of sensitization phenomenon. The sensitization to MET has not been altered in the case of use of JWH in the pretreatment.

In Czech

Rozvoj behaviorální sensitizace k metamfetaminovému účinku na lokomoci u myší není alterován premedikací agonistou CNB2 kanabinoidních receptorů JWH015.