LANDA, Leoš, Alexandra ŠULCOVÁ and Karel ŠLAIS. The influence of cannabinoid CB2 receptor agonist JWH 015 on sensitization to methamphetamine in the model of mouse agonistic behaviour. Homeostasis in Health and Diseases. Milano, Italy: CIANS Homeostasis, 2004, vol. 43, No 1, p. 41-42. ISSN 0960-7560. |
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@article{557234, author = {Landa, Leoš and Šulcová, Alexandra and Šlais, Karel}, article_location = {Milano, Italy}, article_number = {1}, keywords = {behavioural sensitization;CB2 receptor; methamphetamine; JWH-015; agonistic behaviour; mice}, language = {eng}, issn = {0960-7560}, journal = {Homeostasis in Health and Diseases}, title = {The influence of cannabinoid CB2 receptor agonist JWH 015 on sensitization to methamphetamine in the model of mouse agonistic behaviour}, volume = {43}, year = {2004} }
TY - JOUR ID - 557234 AU - Landa, Leoš - Šulcová, Alexandra - Šlais, Karel PY - 2004 TI - The influence of cannabinoid CB2 receptor agonist JWH 015 on sensitization to methamphetamine in the model of mouse agonistic behaviour JF - Homeostasis in Health and Diseases VL - 43 IS - 1 SP - 41-42 EP - 41-42 PB - CIANS Homeostasis SN - 09607560 KW - behavioural sensitization;CB2 receptor KW - methamphetamine KW - JWH-015 KW - agonistic behaviour KW - mice N2 - The aim of the present study was to investigate whether the CB2 receptor activity might also be involved in regulation of mouse agonistic behaviour, and in development of sensitivity to methamphetamine.The CB2 agonist JWH-015 given alone to aggressive singly-housed mice at the doses of 0.1, 1.0 and 10.0 mg/kg intraperitoneally 15 min prior to testing inhibited the occurrence of aggressive activities, significantly of tail rattling and threat after the highest dose. The expression of significant sensitization to MET antiaggressive effects was clear after the pre-treatment with 5 MET doses of 1 mg/kg/day and administration of the "challenge dose" of 1 mg/kg after 5 days of withdrawal. However, the pretreatment with JWH (5 daily doses of 1.0 mg/kg) the cross-sensitization to MET "challenge dose" did not produce in the present study. ER -
LANDA, Leoš, Alexandra ŠULCOVÁ and Karel ŠLAIS. The influence of cannabinoid CB2 receptor agonist JWH 015 on sensitization to methamphetamine in the model of mouse agonistic behaviour. \textit{Homeostasis in Health and Diseases}. Milano, Italy: CIANS Homeostasis, 2004, vol.~43, No~1, p.~41-42. ISSN~0960-7560.
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