LANDA, Leoš, Alexandra ŠULCOVÁ and Karel ŠLAIS. The influence of cannabinoid CB2 receptor agonist JWH 015 on sensitization to methamphetamine in the model of mouse agonistic behaviour. Homeostasis in Health and Diseases. Milano, Italy: CIANS Homeostasis, 2004, vol. 43, No 1, p. 41-42. ISSN 0960-7560.
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Basic information
Original name The influence of cannabinoid CB2 receptor agonist JWH 015 on sensitization to methamphetamine in the model of mouse agonistic behaviour
Name in Czech Vliv agonisty kanabinoidního receptoru CB2 JWH015 na rozvoj sensitizace v modelu agonistického chování myší
Authors LANDA, Leoš (203 Czech Republic, guarantor), Alexandra ŠULCOVÁ (203 Czech Republic) and Karel ŠLAIS (203 Czech Republic).
Edition Homeostasis in Health and Diseases, Milano, Italy, CIANS Homeostasis, 2004, 0960-7560.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30104 Pharmacology and pharmacy
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
RIV identification code RIV/00216224:14110/04:00010239
Organization unit Faculty of Medicine
Keywords in English behavioural sensitization;CB2 receptor; methamphetamine; JWH-015; agonistic behaviour; mice
Tags agonistic behaviour, behavioural sensitization, CB2 receptor, JWH-015, methamphetamine, mice
Changed by Changed by: prof. MUDr. Alexandra Šulcová, CSc., učo 1937. Changed: 29/12/2004 14:33.
Abstract
The aim of the present study was to investigate whether the CB2 receptor activity might also be involved in regulation of mouse agonistic behaviour, and in development of sensitivity to methamphetamine.The CB2 agonist JWH-015 given alone to aggressive singly-housed mice at the doses of 0.1, 1.0 and 10.0 mg/kg intraperitoneally 15 min prior to testing inhibited the occurrence of aggressive activities, significantly of tail rattling and threat after the highest dose. The expression of significant sensitization to MET antiaggressive effects was clear after the pre-treatment with 5 MET doses of 1 mg/kg/day and administration of the "challenge dose" of 1 mg/kg after 5 days of withdrawal. However, the pretreatment with JWH (5 daily doses of 1.0 mg/kg) the cross-sensitization to MET "challenge dose" did not produce in the present study.
Abstract (in Czech)
Rozvoj behaviorální sensitizace k antiagresivnímu účinku metamfetaminu u myší není vyvolán premedikací agonistou CNB2 kanabinoidních receptorů JWH015.
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