NOVÁKOVÁ, Marie. Effect of Sigma Receptor Ligand Haloperidol in Guinea Pig Heart. Acta Veterinaria Brunensis. Brno, 2004, vol. 73, No 3, p. 313-320. ISSN 0001-7213.
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Basic information
Original name Effect of Sigma Receptor Ligand Haloperidol in Guinea Pig Heart
Name in Czech Účinek ligandu sigma receptoru haloperidolu na srdce morčete
Authors NOVÁKOVÁ, Marie (203 Czech Republic, guarantor).
Edition Acta Veterinaria Brunensis, Brno, 2004, 0001-7213.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30105 Physiology
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 0.449
RIV identification code RIV/00216224:14110/04:00011533
Organization unit Faculty of Medicine
UT WoS 000224132100002
Keywords in English cardiac sigma receptor; contractility; mechanical restitution; desensitisation
Tags cardiac sigma receptor, contractility, desensitisation, Mechanical restitution
Changed by Changed by: prof. MUDr. Marie Nováková, Ph.D., učo 1188. Changed: 22/6/2009 17:25.
Abstract
Sigma receptors represent a group of enigmatic binding sites with many functions in different tissues. In rat heart, they are responsible for modulation of cardiac contractility. They are also responsible for some adverse side effects of certain psychotropic drugs on cardiovascular system. In this study, the effect of sigma receptor ligand haloperidol on guinea pig heart multicellular preparations was studied. Its positive inotropic effect previously described in rat cardiomyocytes was confirmed in left atria and papillary muscles isolated from the right ventricles (an increase of the twitch amplitude by 36% to 123% in comparison with the control period in atria and by 9% to 46% in ventricular preparations; all values were statistically significant when compared to control in atrial preparations, but only in the first five min of perfusion in papillary muscles). Also desensitisation process previously reported in rat myocardium after repeated exposure to haloperidol was confirmed (although not statistically significant). The normalized course of mechanical restitution curve was not changed during perfusion with haloperidol. It is concluded that its positive inotropic effect is very likely mediated via increased cytosolic availability of calcium.
Abstract (in Czech)
Sigma receptory představují skupinu vazebných míst s mnoha funkcemi v různých tkáních. V srdci potkana jsou zodpovědné za jemnou modulaci kontraktility. Způsobují také za některé nežádoucí vedlejší účinky psychofarmak na kardiovaskulární systém. Účinek ligandu sigma receptorů haloperidolu na multicelulární preparáty ze srdce morčete byl zkoumán v této práci. Pozitivně inotropní efekt, dříve popsaný u kardiomyocytů potkana, byl potvrzen u levé auriculy a papilárního svalu z pravé komory (zvětšení amplitudy stahu o 36% - 123% ve srovnání s kontrolou u síní a o 9% - 46% u komor; statisticky signifikantní ve srovnání s kontrolou u síní, ale u komor pouze v prvních pěti minutách perfuze). Proces desensitisace popsaný u myokardu potkana po opakované expozici haloperidolu byl také potvrzen (ale NS). Křivka normalizované mechanické restituce se pod vlivem haloperidolu nemění. Lze shrnout, že pozitivně inotropní efekt je velmi pravděpodobně způsoben zvýšenou cytoplazmatickou dostupností kalcia.
Links
GA305/04/1385, research and development projectName: Modulační úloha sigma signalizace na elektromechanické vztahy izolovaného kardiomyocytu a srdce
Investor: Czech Science Foundation, Modulatory role of sigma signalling in electromechanical coupling of isolated cardiomyocyte and heart
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