PISTOVČÁKOVÁ, Jana and Alexandra ŠULCOVÁ. Rat model of depression, behavioural and immune changes after administration of antipsychotic and antiepileptic agents. Homeostasis. Milano, Italy: C.I.A.N.S., 2004, vol. 43, No 1, p. 45-46. ISSN 0960-7560.
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Basic information
Original name Rat model of depression, behavioural and immune changes after administration of antipsychotic and antiepileptic agents
Name in Czech Potkaní model deprese, behaviorální a imunitní změny po podání antipsychotik a antiepileptik
Authors PISTOVČÁKOVÁ, Jana (703 Slovakia) and Alexandra ŠULCOVÁ (203 Czech Republic, guarantor).
Edition Homeostasis, Milano, Italy, C.I.A.N.S. 2004, 0960-7560.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30104 Pharmacology and pharmacy
Country of publisher Italy
Confidentiality degree is not subject to a state or trade secret
RIV identification code RIV/00216224:14110/04:00010257
Organization unit Faculty of Medicine
Keywords in English animal model; depression; antiepileptics; antipsychotics; rat
Tags animal model, antiepileptics, antipsychotics, Depression, rat
Changed by Changed by: MUDr. Jana Pistovčáková, Ph.D., učo 18252. Changed: 6/9/2004 11:44.
Abstract
The olfactory bulbectomy (OB) in rats provides a well established animal model used for screening of drugs with a potential antidepressant activity. While currently some atypical neuroleptics and antiepileptics of the 3rd generation are reported from clinics to show mood stabilizing /antidepressant properties we studied effects of amisulpride (AMS), an atypical antipsychotic agent aproved at present for the treatment of at least dysthymia, and tiagabine (TGB), belonging to the newer antiepileptics, considering their activity in the OB model. Our second objective was to determine in the OB rat model, whether AMS and TGB influence the leukocyte phagocytic activity as a marker of cellular immune function. Only the results of the behavioural part of experiment resemble the reffered effects of classical antidepressants in the OB rats and indicate the hypothesized antidepressant activity of AMS and TGB in the present study.
Abstract (in Czech)
Model olfaktorické bulbektomie u potkanů představuje dobře zavedený model sloužící ke skríningu látek na jejich antidepresivní účinky. Protože se v současnosti některá atypická antipsychotika a antiepileptika 3.generace využívají jako stabilizátory nálady a antidepresiva, testovali jsme účinky amisulpridu, atypického antipsychotika schváleného pro léčbu dysthymie, a antiepileptika třetí generace, tiagabinu ve zmíněném modelu olfaktorické bulbektomie. Dalším cílem bylo shodnotit účinky testovaných látek na leukocytární fagocytózu potkanů, která slouží jako marker funkce buněčné imunity. Pouze behaviorální výsledky po aplikaci amisulpridu a tiagabinu napodobovaly účinky antidepresiv v použitém zvířecím modelu deprese.
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