Memantine influence on sensitization to methamphetamine effects on locomotor/exploratory behaviour in mice

LANDA, Leoš, Karel ŠLAIS, Alexandra ŠULCOVÁ and Mariana HANESOVÁ. Memantine influence on sensitization to methamphetamine effects on locomotor/exploratory behaviour in mice. Psychiatrie. Praha: Tigis, 2004, vol. 8, Suppl. 4, p. 31-31. ISSN 1211-7579.

Basic information

Original name

Memantine influence on sensitization to methamphetamine effects on locomotor/exploratory behaviour in mice

Name (in English)

Memantine influence on sensitization to methamphetamine effects on locomotor/exploratory behaviour in mice

Authors

LANDA, Leoš (203 Czech Republic, guarantor), Karel ŠLAIS (203 Czech Republic), Alexandra ŠULCOVÁ (203 Czech Republic) and Mariana HANESOVÁ (703 Slovakia)

Edition

Psychiatrie, Praha, Tigis, 2004, 1211-7579

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Other information

Language

Czech

Type of outcome

Článek v odborném periodiku

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

RIV identification code

RIV/00216224:14110/04:00010276

Organization unit

Faculty of Medicine

Keywords in English

behavioural sensitization; methamphetamine; memantine; open field test; mice

Tags

behavioural sensitization, Memantine, methamphetamine, mice, open field test

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Abstract

V originále

Methamphetamine (MET) similarly to other psychostimulant drugs invokes during its repeated administration a significant increase in behavioural responses. This phenomenon is termed behavioural sensitization. There are various reports on involvement of N-methyl-D-aspartate (NMDA) receptor activity in the development and expression of behavioural sensitization, although results of them are rather controversial. Thus, the present study was designed to investigate a possible influence of NMDA receptor non-competitive antagonist memantine (MEM) on sensitization to methamphetamine effects on mouse locomotor/exploratory behaviour in the open field test.

In English

Methamphetamine (MET) similarly to other psychostimulant drugs invokes during its repeated administration a significant increase in behavioural responses. This phenomenon is termed behavioural sensitization. There are various reports on involvement of N-methyl-D-aspartate (NMDA) receptor activity in the development and expression of behavioural sensitization, although results of them are rather controversial. Thus, the present study was designed to investigate a possible influence of NMDA receptor non-competitive antagonist memantine (MEM) on sensitization to methamphetamine effects on mouse locomotor/exploratory behaviour in the open field test.