SMILEK, Pavel, Rom KOSTŘICA, Jan ROTTENBERG, Karel VESELÝ and Ladislav DUŠEK. PREDICTIVE PARAMETERS OF THE WALDEYERS RING CARCINOMAS (A RETROSPECTIVE STUDY). In 5th European congress of Oto-Rhino-Laryngology head and Neck Surgery Abstract Book. Athény, Řecko: C and C International S.A., 2004, p. 234.
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Basic information
Original name PREDICTIVE PARAMETERS OF THE WALDEYERS RING CARCINOMAS (A RETROSPECTIVE STUDY)
Name (in English) PREDICTIVE PARAMETERS OF THE WALDEYERS RING CARCINOMAS (A RETROSPECTIVE STUDY)
Authors SMILEK, Pavel (203 Czech Republic, guarantor), Rom KOSTŘICA (203 Czech Republic), Jan ROTTENBERG (203 Czech Republic), Karel VESELÝ (203 Czech Republic) and Ladislav DUŠEK (203 Czech Republic).
Edition Athény, Řecko, 5th European congress of Oto-Rhino-Laryngology head and Neck Surgery Abstract Book, p. 234-234, 2004.
Publisher C and C International S.A.
Other information
Original language Czech
Type of outcome Proceedings paper
Field of Study 30200 3.2 Clinical medicine
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
RIV identification code RIV/00216224:14110/04:00010301
Organization unit Faculty of Medicine
Keywords in English head and neck cancer; predictiv parameters
Tags head and neck cancer, predictiv parameters
Changed by Changed by: doc. MUDr. Pavel Smilek, Ph.D., učo 1801. Changed: 20/9/2004 11:49.
Abstract
The analysis was carried out with a set of 60 patients suffering from carcinoma of the pharynx and supraglottis. Besides routine examinations, flow cytometric analysis of was performed, p53 and Ki-67 markers were established by means of immunohistochemistry. Furthermore mitotic and apoptotic index were established. Event-free survival (EFS) and overall survival (OS) were accepted as primary endpoints for the prognostic analyses. Cytokinetic parameters and proliferation activity were found as important predictors of the second level (after recognizing stage, grade and DNA status of the tumor). Multivariate combination of these markers contributed namely to the prognosis of early risk event (i.e. progression or relapse of the disease up to 12 months after the end of the therapy): ratio SPF/G2M cell fractions was found to be the key prognostic factor (p < 0.01). Early progressed cases have typically decreased SPF fraction combined with increased mitotic activity.
Abstract (in English)
The analysis was carried out with a set of 60 patients suffering from carcinoma of the pharynx and supraglottis. Besides routine examinations, flow cytometric analysis of was performed, p53 and Ki-67 markers were established by means of immunohistochemistry. Furthermore mitotic and apoptotic index were established. Event-free survival (EFS) and overall survival (OS) were accepted as primary endpoints for the prognostic analyses. Cytokinetic parameters and proliferation activity were found as important predictors of the second level (after recognizing stage, grade and DNA status of the tumor). Multivariate combination of these markers contributed namely to the prognosis of early risk event (i.e. progression or relapse of the disease up to 12 months after the end of the therapy): ratio SPF/G2M cell fractions was found to be the key prognostic factor (p < 0.01). Early progressed cases have typically decreased SPF fraction combined with increased mitotic activity.
Links
MSM 141100003, plan (intention)Name: Zevní prostředí - karcinogeneze - onkologie
Investor: Ministry of Education, Youth and Sports of the CR, Environment - carcinogenesis - oncology
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