HADAŠOVÁ, Eva, Miroslav DOSTÁLEK, Jan JUŘICA, Josef TOMANDL and Veronika MINAŘÍKOVÁ. METHAMPHETAMINE-INDUCED CHANGES IN DEXTROMETHORPHAN AND MIDAZOLAM METABOLISM IN RATS: A PHARMACOKINETIC STUDY. In 19th European Workshop on Drug Metabolism. Abstract & Program Book. Antalya (Turecko): Tubitak, 2004, p. 194-194.
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Basic information
Original name METHAMPHETAMINE-INDUCED CHANGES IN DEXTROMETHORPHAN AND MIDAZOLAM METABOLISM IN RATS: A PHARMACOKINETIC STUDY
Name in Czech Methamfetaminem indukované změny v metabolismu dextromethorfanu a midazolamu u potkanů: farmakokinetická studie
Authors HADAŠOVÁ, Eva (203 Czech Republic, guarantor), Miroslav DOSTÁLEK (203 Czech Republic), Jan JUŘICA (203 Czech Republic), Josef TOMANDL (203 Czech Republic) and Veronika MINAŘÍKOVÁ (203 Czech Republic).
Edition Antalya (Turecko), 19th European Workshop on Drug Metabolism. Abstract & Program Book. p. 194-194, 1 pp. 2004.
Publisher Tubitak
Other information
Original language English
Type of outcome Proceedings paper
Field of Study 30104 Pharmacology and pharmacy
Country of publisher Turkey
Confidentiality degree is not subject to a state or trade secret
RIV identification code RIV/00216224:14110/04:00010419
Organization unit Faculty of Medicine
Keywords in English drug metabolism; methamphetamine; dextromethorphan; midazolam; CYP2D6; CYP3A4; pharmacokinetics;
Tags CYP2D6, CYP3A4, dextromethorphan, drug metabolism, methamphetamine, midazolam, pharmacokinetics
Changed by Changed by: doc. RNDr. Josef Tomandl, Ph.D., učo 47. Changed: 8/2/2005 13:07.
Abstract
Methamphetamine (pervitine) is one of the most frequently abused substances. The drug is metabolized by the hepatic cytochromes P450, mainly by CYP2D and CYP3A. The present pharmacokinetic study in the rat investigated the possible influence of methamphetamine on metabolic fates of model substrates for CYP3A1/2 and CYP2D1/2. The pharmacokinetic analysis showed a marked stimulatory effect of methamphetamine on CYP2D1/2, as it was previously demonstrated by us in the isolated perfused rat liver. Similarly, the midazolam kinetics (marker of CYP3A1/2 activity) showed a significantly increased CYP3A-mediated metabolism. The results may have clinical impact in pharmacotherapy of methamphetamine abusers.
Abstract (in Czech)
Methamfetaminem indukované změny v metabolismu dextromethorfanu a midazolamu u potkanů: farmakokinetická studie
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