ASTIER, Anne, Marek SVOBODA, Esther HINDS, Rosalie DE BEAUMONT, Olivier MUNOZ and Arnold Stephen FREEDMAN. Integrins regulate survival of pre-B-ALL cells through differential IAP and caspase-7 ubiquitination and degradation. Leukemia. 2004, Vol. 18, No 4, p. 873-875. ISSN 0887-6924. |
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@article{561101, author = {Astier, Anne and Svoboda, Marek and Hinds, Esther and de Beaumont, Rosalie and Munoz, Olivier and Freedman, Arnold Stephen}, article_number = {4}, keywords = {Leukemia;Apoptosis;IAPs;Ubiquitination;Microarrays;Caspases}, language = {eng}, issn = {0887-6924}, journal = {Leukemia}, title = {Integrins regulate survival of pre-B-ALL cells through differential IAP and caspase-7 ubiquitination and degradation.}, volume = {Vol. 18}, year = {2004} }
TY - JOUR ID - 561101 AU - Astier, Anne - Svoboda, Marek - Hinds, Esther - de Beaumont, Rosalie - Munoz, Olivier - Freedman, Arnold Stephen PY - 2004 TI - Integrins regulate survival of pre-B-ALL cells through differential IAP and caspase-7 ubiquitination and degradation. JF - Leukemia VL - Vol. 18 IS - 4 SP - 873-875 EP - 873-875 SN - 08876924 KW - Leukemia;Apoptosis;IAPs;Ubiquitination;Microarrays;Caspases N2 - The interactions between integrins and their ligands rescue normal and neoplastic B cells from apoptosis in several ways. The first we have found that integrin stimulation enhances the amount of antiapoptotic proteins from the IAP family members. Second, to further control the levels of these proteins, integrins regulate their proteasomal degradation by controlling their level of ubiquitination. Indeed, the understanding of the well-defined mechanisms controlling apoptosis might provide future therapeutic strategies to modulate the survival of neoplastic B cells. ER -
ASTIER, Anne, Marek SVOBODA, Esther HINDS, Rosalie DE BEAUMONT, Olivier MUNOZ and Arnold Stephen FREEDMAN. Integrins regulate survival of pre-B-ALL cells through differential IAP and caspase-7 ubiquitination and degradation. \textit{Leukemia}. 2004, Vol. 18, No~4, p.~873-875. ISSN~0887-6924.
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