Sertindole has an antidepressant-like effect on behaviour and immune system in the bilaterally olfactory bulbectomized rats

PISTOVČÁKOVÁ, Jana and Alexandra ŠULCOVÁ. Sertindole has an antidepressant-like effect on behaviour and immune system in the bilaterally olfactory bulbectomized rats. In FENS Forum Abstracts. vol 2. Portugal: Forum of European Neuroscience Societies, 2004, p. A234.4, 1 pp.

Basic information

• Original name: Sertindole has an antidepressant-like effect on behaviour and immune system in the bilaterally olfactory bulbectomized rats
• Name in Czech: Sertindol má v modelu bilaterální olfaktorické bulbektomie potkanů behaviorální a imunitní účinky podobné účinkům antidepresiv
• Authors: PISTOVČÁKOVÁ, Jana (703 Slovakia) and Alexandra ŠULCOVÁ (203 Czech Republic, guarantor).
• Edition: vol 2. Portugal, FENS Forum Abstracts, p. A234.4, 1 pp. 2004.
• Publisher: Forum of European Neuroscience Societies

Other information

• Original language: English
• Type of outcome: Proceedings paper
• Field of Study: 30104 Pharmacology and pharmacy
• Country of publisher: Portugal
• Confidentiality degree: is not subject to a state or trade secret
• RIV identification code: RIV/00216224:14110/04:00010519
• Organization unit: Faculty of Medicine
• Keywords in English: depression; atypical antipsychotic; sertindole; olfactory bulbectiomy; rat
• Tags: Atypical antipsychotic, Depression, olfactory bulbectiomy, rat, sertindole

Abstract

The effects of atypical neuroleptic sertindole was studied in the rodent model of depression, the olfactory bulbectomized (OB) rat. OB rats are known to exhibit abnormal hyperactive response to a stressful situation in the open field test and alterations of the immune system functions. The open field test was performed in both sham-operated and OB rats and their locomotor activity recorded by the infra-red sensor tracking system Actitrack (Panlab, S. L., Spain). The activity of leukocyte zymosan-induced phagocytosis was examined via measurement of chemiluminiscence potentiated by luminol. In sertindol (2 mg/kg/day, 10 days i. p. ) treated OB rats a significant (p<0.05) inhibition of the OB-related hyperactivity was observed. Sertindol did not produce any sedative effect on the locomotion of the sham-operated rats. In the OB rats there was a signifficant suppression of the leukocyte phagocytic activity in comparison with the sham rats, which was disinhibited (p<0.05) by sertindol treatment (2 mg/kg/day, 10 days i. p. ). Thus, the present results confirmed an antidepressant-like impact of sertindol on both behavioural and immune parameters in the OB rat model of depression.

Abstract (in Czech)

Sledovali jsme účinky atypického neuroleptika sertindolu v potkaním modelu bilaterální olfaktorické bulbektomie. Bulbektomovaná zvířata projevují typickou lokomotorickou hyperaktivitu v testu otevřeného pole a poruchy imunitních funkcí. Záznam lokomoční aktivity byl pořízen pomocí systému infračervených senzorů Actitrack (Panlab, S. L., Spain). Aktivita leukocytární fagocytózy navozené zymosanem a potencované luminolem byla u bulbektomovaných zvířat potlačena. Sertindol (2 mg/kg/day, 10 dnů, i. p.) signifikantně inhiboval (p<0.05) lokomoční hyperaktivitu navozenou bulbektomií, bez negativního ovlivnění lokomoce kontrolních zvířat. Sertindol rovněž signifikantně (p<0.05) stimuloval leukocytární fagocytózu u bulbektomovaných potkanů. Behaviorální i imunitní výsledky po desetidenní aplikaci sertindolu svědčí pro potenciální antidepresivní účinky sertindolu ve zvířecím modelu deprese, bilaterální olfaktorické bulbektomie.