Effect of St. Johns wort (Hypericum perforatum) standardized extract on leukocyte phagocytosis in rat model of depression

PISTOVČÁKOVÁ, Jana, Miroslav DOSTÁLEK, Jan JUŘICA, Josef TOMANDL, Ivan LINHART, Alexandra ŠULCOVÁ and Eva HADAŠOVÁ. Effect of St. Johns wort (Hypericum perforatum) standardized extract on leukocyte phagocytosis in rat model of depression. Psychiatrie. Praha: Tigis, s.r.o., 2004, vol. 8, Suppl.4, p. 39-40. ISSN 1211-7579.

Basic information

Original name

Effect of St. Johns wort (Hypericum perforatum) standardized extract on leukocyte phagocytosis in rat model of depression

Name in Czech

Účinek standardizovaného extraktu z třezalky na leukocytární fagocytózu v potkaním modelu deprese.

Authors

PISTOVČÁKOVÁ, Jana (703 Slovakia), Miroslav DOSTÁLEK (203 Czech Republic), Jan JUŘICA (203 Czech Republic), Josef TOMANDL (203 Czech Republic), Ivan LINHART (203 Czech Republic), Alexandra ŠULCOVÁ (203 Czech Republic) and Eva HADAŠOVÁ (203 Czech Republic, guarantor)

Edition

Psychiatrie, Praha, Tigis, s.r.o. 2004, 1211-7579

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Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

RIV identification code

RIV/00216224:14110/04:00010521

Organization unit

Faculty of Medicine

Keywords in English

depression; Hypericum perforatum; LI160; rat; olfactory bulbectomy; immunity; leukocyte phagocytosis

Tags

Depression, hypericum perforatum, immunity, leukocyte phagocytosis, LI160, olfactory bulbectomy, rat

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Abstract

V originále

The effects of St. Johns wort (standardized herbal extract LI 160) on leukocyte phagocytic activity in the rodent model of depression, the olfactory bulbectomized (OB) rat were studied. The activity of leukocyte zymosan-induced phagocytosis was examined via measurement of chemiluminiscence potentiated by luminol. The results confirm an antidepressant-like behavioural impact of LI 160 (100 mg/kg/day, 10 days i.p.) in the OB rat model of depression. In the OB rats there was a signifficant suppression of the leukocyte phagocytic activity in comparison with the sham rats, which was disinhibited (p<0.05) by LI 160 (100 mg/kg/day, 10 days i.p.). However the dose used was generally immunostimulatory active as the increase in leukocyte phagocytosis (p<0.001) was found also in the control group of rats. This immunostimulant effect of the St. Johns wort standardized extract LI 160 might be important in clinics and deserves further investigation.

In Czech

The effects of St. Johns wort (standardized herbal extract LI 160) on leukocyte phagocytic activity in the rodent model of depression, the olfactory bulbectomized (OB) rat were studied. The activity of leukocyte zymosan-induced phagocytosis was examined via measurement of chemiluminiscence potentiated by luminol. The results confirm an antidepressant-like behavioural impact of LI 160 (100 mg/kg/day, 10 days i.p.) in the OB rat model of depression. In the OB rats there was a signifficant suppression of the leukocyte phagocytic activity in comparison with the sham rats, which was disinhibited (p<0.05) by LI 160 (100 mg/kg/day, 10 days i.p.). However the dose used was generally immunostimulatory active as the increase in leukocyte phagocytosis (p<0.001) was found also in the control group of rats. This immunostimulant effect of the St. Johns wort standardized extract LI 160 might be important in clinics and deserves further investigation.