Detailed Information on Publication Record
2005
Haplotype analysis of the RAGE gene: identification of a haplotype marker for diabetic nephropathy in type 2 diabetes mellitus
KAŇKOVÁ, Kateřina, Andrea STEJSKALOVÁ, Miluše HERTLOVÁ and Vladimír ZNOJILBasic information
Original name
Haplotype analysis of the RAGE gene: identification of a haplotype marker for diabetic nephropathy in type 2 diabetes mellitus
Name in Czech
Haplotypova analyza genu pro RAGE: identifikace haplotypoveho markeru pro diabetickou nefropatii u diabetu 2. typu
Authors
KAŇKOVÁ, Kateřina (203 Czech Republic, guarantor), Andrea STEJSKALOVÁ (203 Czech Republic), Miluše HERTLOVÁ (203 Czech Republic) and Vladimír ZNOJIL (203 Czech Republic)
Edition
Nephrology Dialysis Transplantation, United Kingdom, Oxford University Press, 2005, 0931-0509
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30202 Endocrinology and metabolism
Country of publisher
United Kingdom of Great Britain and Northern Ireland
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 2.976
RIV identification code
RIV/00216224:14110/05:00012342
Organization unit
Faculty of Medicine
UT WoS
000229704600012
Keywords in English
AGEs; complications; diabetic nephropathy; haplotype analysis; polymorphism; RAGE
Změněno: 23/6/2009 15:21, prof. MUDr. Kateřina Kaňková, Ph.D.
V originále
Background: Diabetic nephropathy (DN) represents a devastating complication of diabetes. Family clustering, heterogeneity in the onset and progression and results of segregation studies indicate that susceptibility to DN is a complex trait. Methods: Common SNPs in RAGE (Receptor of Advanced Glycation End products) gene (-429T/C, -374T/A, G82S, 1704G/T, 2184A/G and 2245G/A) were studied in the association study comprising 605 Caucasian subjects by means of haplotype analysis in order to identify an eventual haplotype marker for DN in type 2 diabetes. Haplotypes were constructed computationally; frequencies were compared among groups of subjects with type 2 diabetes and DN, diabetics without DN and non-diabetics. Survival analysis was carried out to ascertain whether certain RAGE haplotypes influence onset of DN in type 2 diabetics. Results: Significant differences in haplotype frequencies among DM+DN vs. DM non-DN and non-DM groups were found (P=0.0007 and P=0.0013, respectively, permutation test). Frequency of the RAGE2 haplotype containing minor alleles in positions -429 and 2184 (CTGGGG) in the DN group was significantly higher than in the two control groups (21.7 vs. 12.8 and 13.8%, both Pcorr<0.003, two-tail Fisher-exact test); ORs 1.65 [95% CI 1.08 - 2.50], P=0.020 and 1.79 [95% CI 1.22 - 2.62], P=0.003, respectively. In survival analysis, duration of diabetes until the onset of DN (e.g. appearance of persistent proteinuria) was significantly different among RAGE2 diplotype groups (P<0.05); median DN-free interval was 9.6 years in RAGE2 +/+ homozygotes, 15.2 years in +/- heterozygotes and 17.0 years in the -/- combination. Conclusions: The RAGE2 haplotype is associated with DN in type 2 diabetics and with earlier DN onset, and thus can be regarded a marker for DN.
In Czech
Zjistili jsme statisticky vyznamnou asociaci RAGE2 haplotypu s diabetickou nefropatii a rovnez s casnejsim nastupem diabeicke nefropatie. RAGE2 muze byt tudiz povazovan za geneticky marker diabeticke nefropatie.
Links
| GP303/02/D127, research and development project |
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| LZ1K03019, research and development project |
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| MSM 141100002, plan (intention) |
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