| NOVÁKOVÁ, Jana a Alexandra ŠULCOVÁ. Comparison of the role of 5-HT1 and 5-HT2 receptors in the regulation of locomotor/exploratory behaviour in rats. Online. Homeostasis. Milano, Italy: C.I.A.N.S., 2004, roč. 43, č. 1, s. 46-48. ISSN 0960-7560. [citováno 2024-04-23] |
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@article{562911,
author = {Nováková, Jana and Šulcová, Alexandra},
article_location = {Milano, Italy},
article_number = {1},
keywords = {serotonin-5-HT1 and 5-HT2 receptor ligands-locomotor/exploratory behaviour-rats},
language = {eng},
issn = {0960-7560},
journal = {Homeostasis},
title = {Comparison of the role of 5-HT1 and 5-HT2 receptors in the regulation of locomotor/exploratory behaviour in rats},
volume = {43},
year = {2004}
}
TY - JOUR
ID - 562911
AU - Nováková, Jana - Šulcová, Alexandra
PY - 2004
TI - Comparison of the role of 5-HT1 and 5-HT2 receptors in the regulation of locomotor/exploratory behaviour in rats
JF - Homeostasis
VL - 43
IS - 1
SP - 46-48
EP - 46-48
PB - C.I.A.N.S.
SN - 09607560
KW - serotonin-5-HT1 and 5-HT2 receptor ligands-locomotor/exploratory behaviour-rats
N2 - The aim of the present study was to ascertain the role of serotonin (5-HT) on locomotor/exploratory behaviour in laboratory rats. In the experiments, activity of selected 5-HT receptor subtypes was manipulated by exogenous administration of their ligands. We focused on the evaluation of influence of 5-HT1A and 5-HT1B selective receptor ligands, and furthermore non-selective 5-HT2 receptor agents. We used two behavioural tests: "staircase test" (climbing the stairs and rearing are recorded) and "open field" test performed by Actitrack apparatus (Panlab, S.L., Spain) that enables recording of wide range of behavioural parameters. In comparison of the influences of all 5-HT1A, 5-HT1B and 5-HT2 ligands tested on spontaneous locomotor/exploratory activities of animals there has been shown that the selective 5-HT1A mimetic agent 8-OH-DPAT possesses the most significant inhibitory efficacy.Present results underline the role of 5-HT1A receptor subtype in the mediation of locomotor/exploratory behaviour in animals and such observations should be of significance to experimental and clinical studies of the influence of 5-HT1A agonists upon depressive and anxiety disorders.
ER -
NOVÁKOVÁ, Jana a Alexandra ŠULCOVÁ. Comparison of the role of 5-HT1 and 5-HT2 receptors in the regulation of locomotor/exploratory behaviour in rats. Online. \textit{Homeostasis}. Milano, Italy: C.I.A.N.S., 2004, roč.~43, č.~1, s.~46-48. ISSN~0960-7560. [citováno 2024-04-23]
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