J 2004

Involvement of 5-HT1 and 5-HT2 receptor activity in methamphetamine i.v. self-administration in rats depressed by olfactory bulbectomy

NOVÁKOVÁ, Jana, Jana PISTOVČÁKOVÁ, Jana VINKLEROVÁ and Alexandra ŠULCOVÁ

Basic information

Original name

Involvement of 5-HT1 and 5-HT2 receptor activity in methamphetamine i.v. self-administration in rats depressed by olfactory bulbectomy

Name in Czech

Vliv 5-HT1 a 5-HT2 receptorů na aktivitu v i.v. self-administraci metamfetaminu u potkanů v modelu deprese vyvolané olfaktorickou bulbektomií

Authors

NOVÁKOVÁ, Jana (203 Czech Republic, guarantor), Jana PISTOVČÁKOVÁ (703 Slovakia), Jana VINKLEROVÁ (203 Czech Republic) and Alexandra ŠULCOVÁ (203 Czech Republic)

Edition

Fundamental & Clinical Pharmacology, UK, Blackwell Publishing, 2004, 1744-3377

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

RIV identification code

RIV/00216224:14110/04:00010699

Organization unit

Faculty of Medicine

UT WoS

000208663600232

Keywords in English

rats; 5-HT1 and 5-HT2 receptor ligands; methamphetamine; dependence; depression
Změněno: 16/5/2005 10:58, prof. MUDr. Alexandra Šulcová, CSc.

Abstract

V originále

The influence of 5-HT1 and 5-HT2 receptor antagonists on methamphetamine intake was analysed in both, naive rats and those depressed by olfactory bulbectomy. Our results indicate that the involvement of 5-HT2 rather than 5-HT1 receptor is important for methamphetamine reward properties what corresponds with the outcomes of methamphetamine discriminative studies. Thus, 5-HT2 receptor antagonists referred to attenuate the withdrawal signs of drugs of abuse could be of benefit also in treatment of methamphetamine dependence, mainly in addicts with depressive disorders.

In Czech

Výsledky ukazují na významný podíl aktivity 5-HT2 receptorového systémů v procesech odměny u potaknů v modelu deprese.