Detailed Information on Publication Record
2004
Involvement of 5-HT1 and 5-HT2 receptor activity in methamphetamine i.v. self-administration in rats depressed by olfactory bulbectomy
NOVÁKOVÁ, Jana, Jana PISTOVČÁKOVÁ, Jana VINKLEROVÁ and Alexandra ŠULCOVÁBasic information
Original name
Involvement of 5-HT1 and 5-HT2 receptor activity in methamphetamine i.v. self-administration in rats depressed by olfactory bulbectomy
Name in Czech
Vliv 5-HT1 a 5-HT2 receptorů na aktivitu v i.v. self-administraci metamfetaminu u potkanů v modelu deprese vyvolané olfaktorickou bulbektomií
Authors
NOVÁKOVÁ, Jana (203 Czech Republic, guarantor), Jana PISTOVČÁKOVÁ (703 Slovakia), Jana VINKLEROVÁ (203 Czech Republic) and Alexandra ŠULCOVÁ (203 Czech Republic)
Edition
Fundamental & Clinical Pharmacology, UK, Blackwell Publishing, 2004, 1744-3377
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30104 Pharmacology and pharmacy
Country of publisher
United Kingdom of Great Britain and Northern Ireland
Confidentiality degree
není předmětem státního či obchodního tajemství
RIV identification code
RIV/00216224:14110/04:00010699
Organization unit
Faculty of Medicine
UT WoS
000208663600232
Keywords in English
rats; 5-HT1 and 5-HT2 receptor ligands; methamphetamine; dependence; depression
Tags
Změněno: 16/5/2005 10:58, prof. MUDr. Alexandra Šulcová, CSc.
V originále
The influence of 5-HT1 and 5-HT2 receptor antagonists on methamphetamine intake was analysed in both, naive rats and those depressed by olfactory bulbectomy. Our results indicate that the involvement of 5-HT2 rather than 5-HT1 receptor is important for methamphetamine reward properties what corresponds with the outcomes of methamphetamine discriminative studies. Thus, 5-HT2 receptor antagonists referred to attenuate the withdrawal signs of drugs of abuse could be of benefit also in treatment of methamphetamine dependence, mainly in addicts with depressive disorders.
In Czech
Výsledky ukazují na významný podíl aktivity 5-HT2 receptorového systémů v procesech odměny u potaknů v modelu deprese.