Detailed Information on Publication Record
2004
A haplotype constituted of four MMP-2 promoter polymorphisms (-1575G/A, -1306C/T, -790T/G and -735C/T) is associated with coronary triple- vessel disease
VAŠKŮ, Anna, Monika PÁVKOVÁ GOLDBERGOVÁ, Lydie IZAKOVIČOVÁ HOLLÁ, Lenka ŠIŠKOVÁ, Ladislav GROCH et. al.Basic information
Original name
A haplotype constituted of four MMP-2 promoter polymorphisms (-1575G/A, -1306C/T, -790T/G and -735C/T) is associated with coronary triple- vessel disease
Name in Czech
Haplotyp čtyř polymorfismů v promotoru genu pro MMP-2 (-1575G/A, -1306C/T, -790T/G a -735C/T) je asociován s nemocí tří koronárních tepen
Authors
VAŠKŮ, Anna (203 Czech Republic, guarantor), Monika PÁVKOVÁ GOLDBERGOVÁ (203 Czech Republic), Lydie IZAKOVIČOVÁ HOLLÁ (203 Czech Republic), Lenka ŠIŠKOVÁ (203 Czech Republic), Ladislav GROCH (203 Czech Republic), Michal BERÁNEK (203 Czech Republic), Svatava TSCHÖPLOVÁ (203 Czech Republic), Vladimír ZNOJIL (203 Czech Republic) and Jiří VÁCHA (203 Czech Republic)
Edition
Matrix Biology, Elsevier B.V. 2004, 0945-053X
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30201 Cardiac and Cardiovascular systems
Country of publisher
United States of America
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 4.104
RIV identification code
RIV/00216224:14110/04:00010702
Organization unit
Faculty of Medicine
UT WoS
000220275700008
Keywords in English
Triple-vessel disease; Matrix metalloproteinases; Atherosclerotic plaque
Změněno: 17/6/2009 11:56, prof. MUDr. Lydie Izakovičová Hollá, Ph.D.
V originále
Vascular lesion development is associated with an accumulation of extracellular matrix proteins within the vessel wall. The proteins are degraded by matrix metalloproteinases. There is also evidence indicating a participation of the MMPs in the weakening of atherosclerotic plaque that predisposes to lesion disruption. The aim of the study was to test an association among haplotypes of four single nucleotide MMP-2 promoter polymorphisms and the angiographically confirmed coronary triplevessel disease. Incidence of haplotypes of four MMP-2 promoter polymorphisms (-1575 G/A, -1306C/T, -790T/G and -735C/T) determined by PCR reactions with restriction analyses in 187 patients with coronary triple-vessel disease (153 men, 34 women, age median 65 years) was compared to 196 control subjects without clinical signs of CHD (131 men and 65 women, age median 60 years).The incidence of two similar haplotypes was found to be different between patients and healthy subjects. The haplotype GCTC was more frequent in the triple vessel disease patients (P=0.01) though the haplotype GCGC was identified only in healthy subjects (P=0.001). Interestingly, the GCTC is the most frequent polymorphic haplotype composed of four promoter SNPs localized in the MMP-2 gene (53% in healthy subjects vs. 66 % in patients with triple-vessel disease), and the haplotype GCGC is the least frequent polymorphic one (4.4% in healthy subjects vs. 0 % in patients with triple-vessel disease).Two different MMP-2 promoter haplotypes differing only in -790T/G allele are significantly more or less frequent in coronary triple-vessel disease compared to non-ischemic persons. Thus, the -790 T/G MMP-2 genotype might be used as a genetic marker representing MMP-2 promoter variability for the triple vessel disease with odds ratio for TT and TG genotype 2.59, 95% confidential interval 1.21-5.55, P=0.009. The analysis of promoter MMP-2 gene variability could help us to understand individual susceptibility to MMP inhibitor treatment of the coronary artery disease.
In Czech
Rozvoj poškození cévní stěny je asociován s akumulací proteinů extracelulární matrix. Tyto proteiny jsou degradovány matrix metaloproteinázami. Cílem studie bylo proto testovat asociaci mezi haplotypy čtyř promotorových polymorfismů a nemocí tří koronárních tepen, potvrzenou angiograficky. Frekvence haplotypů byly srovnány se skupinou 196 kontrolních osob bez klinických příznaků koronární nemoci. Prokázali jsme, že haplotyp GCTC byl častěji přítomen u pacientů (P=0,01), kdežto haplotyp GCGC byl pozorován jen u zdravých osob(P=0,001).
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