J 2004

Methamphetamine increases CYP2D1/2 activity in isolated perfused rat liver

DOSTÁLEK, Miroslav, Veronika MINAŘÍKOVÁ, Jan JUŘICA, Josef TOMANDL, Eva HADAŠOVÁ et. al.

Basic information

Original name

Methamphetamine increases CYP2D1/2 activity in isolated perfused rat liver

Name in Czech

Mmetamfetamin zvyšuje aktivtu CYP2D v systému izolovaných perfundovaných jater

Name (in English)

Methamphetamine increases CYP2D1/2 activity in isolated perfused rat liver

Authors

DOSTÁLEK, Miroslav (203 Czech Republic), Veronika MINAŘÍKOVÁ (203 Czech Republic), Jan JUŘICA (203 Czech Republic), Josef TOMANDL (203 Czech Republic) and Eva HADAŠOVÁ (203 Czech Republic, guarantor)

Edition

Psychiatrie, Praha, Tigis, 2004, 1211-7579

Other information

Language

Czech

Type of outcome

Článek v odborném periodiku

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

RIV identification code

RIV/00216224:14110/04:00010750

Organization unit

Faculty of Medicine

Keywords in English

methamphetamine; rat; liver

Tags

Změněno: 31/5/2005 10:10, PharmDr. Miroslav Dostálek, Ph.D.

Abstract

ORIG EN

V originále

Methamphetamine represents a significant drug abuse problem in many European countries including the Czech republic. Studies in human liver microsomes have shown that crucial metabolic reactions of MeAmp are catalyzed by CYP2D6; furthermore, some amphetamine analogues were reported as inhibitors of CYP2D6 (Wu et. al., 1997). The aim of the study was to ascertain the influence of acute and repeated pretreatment of rats with various doses of methamphetamine on metabolic activity of CYP2D1/2 (correlate of human CYP2D6) in the isolated perfused rat liver.

In English

Methamphetamine increases CYP2D1/2 activity in isolated perfused rat liver