Detailed Information on Publication Record
2004
Clustering of genes with similar regulation patterns during monocyte and granulocyte differentiation of HL-60 cells
KOUTNÁ, Irena, Eva JANSOVÁ, Petr KRONTORÁD, Zbyněk SVOBODA, Tomáš PAVLÍK et. al.Basic information
Original name
Clustering of genes with similar regulation patterns during monocyte and granulocyte differentiation of HL-60 cells
Name in Czech
Shlukování genů s podobnými regulačními vzory během monocytické a granulocytické diferenciace buněk HL-60
Authors
KOUTNÁ, Irena (203 Czech Republic), Eva JANSOVÁ (203 Czech Republic), Petr KRONTORÁD (203 Czech Republic), Zbyněk SVOBODA (203 Czech Republic), Tomáš PAVLÍK (203 Czech Republic), Eva BÁRTOVÁ (203 Czech Republic), Michal KOZUBEK (203 Czech Republic, guarantor) and Stanislav KOZUBEK (203 Czech Republic)
Edition
First Edition 2004. Brno, Biophysics of the Genome, p. 38-43, 6 pp. 2004
Publisher
Masaryk University
Other information
Language
English
Type of outcome
Stať ve sborníku
Field of Study
Genetics and molecular biology
Country of publisher
Czech Republic
Confidentiality degree
není předmětem státního či obchodního tajemství
RIV identification code
RIV/00216224:14330/04:00010790
Organization unit
Faculty of Informatics
ISBN
80-210-3560-9
Keywords in English
microarrayc
Tags
Tags
International impact
Změněno: 29/10/2010 14:35, prof. RNDr. Michal Kozubek, Ph.D.
V originále
In the present study, a high density-microarrays of human cDNA containing 19,000 genetic elements were used to search for differences in gene expression of human promyelic leukaemia cell line HL-60 during monocyte (MD) and granulocyte differentiation (GD). For differentiation to monocytes (granulocytes), the TPA, 12-O-tetradecanoylphorbol-13-acetate (DMSO) were used, respectively. A total number of 4625 (4760) genes were found to be regulated during MD (GD). The genes have been divided into groups according to their kinetics of regulation (R-groups). The genes of the same group are not distributed randomly throughout the genome but form clusters on chromosomes (R-clusters). Thus, functionally interconnected genes are frequently localized near to each other on the DNA molecule. In addition, genes of R-groups of MD (GD), if projected to GD (MD) happen to be mostly found in one or several R-groups of the other type, although the kinetics of regulation may be different (e.g. group 9 of GD and group 12 of MD). However, in most cases similar patterns of regulation correspond to each other (15, 16 of GD correspond to 3, 4 of MD).
In Czech
Shlukování genů s podobnými regulačními vzory během monocytické a granulocytické diferenciace buněk HL-60.
Links
| GP301/04/P136, research and development project |
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| MSM 143300002, plan (intention) |
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| 1A8241, research and development project |
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