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@inproceedings{563691,
author = {Koutná, Irena and Jansová, Eva and Krontorád, Petr and Svoboda, Zbyněk and Pavlík, Tomáš and Bártová, Eva and Kozubek, Michal and Kozubek, Stanislav},
address = {Brno},
booktitle = {Biophysics of the Genome},
edition = {First Edition 2004},
keywords = {microarrayc},
language = {eng},
location = {Brno},
isbn = {80-210-3560-9},
pages = {38-43},
publisher = {Masaryk University},
title = {Clustering of genes with similar regulation patterns during monocyte and granulocyte differentiation of HL-60 cells},
year = {2004}
}
TY - JOUR
ID - 563691
AU - Koutná, Irena - Jansová, Eva - Krontorád, Petr - Svoboda, Zbyněk - Pavlík, Tomáš - Bártová, Eva - Kozubek, Michal - Kozubek, Stanislav
PY - 2004
TI - Clustering of genes with similar regulation patterns during monocyte and granulocyte differentiation of HL-60 cells
PB - Masaryk University
CY - Brno
SN - 8021035609
KW - microarrayc
N2 - In the present study, a high density-microarrays of human cDNA containing 19,000 genetic elements were used to search for differences in gene expression of human promyelic leukaemia cell line HL-60 during monocyte (MD) and granulocyte differentiation (GD). For differentiation to monocytes (granulocytes), the TPA, 12-O-tetradecanoylphorbol-13-acetate (DMSO) were used, respectively. A total number of 4625 (4760) genes were found to be regulated during MD (GD). The genes have been divided into groups according to their kinetics of regulation (R-groups). The genes of the same group are not distributed randomly throughout the genome but form clusters on chromosomes (R-clusters). Thus, functionally interconnected genes are frequently localized near to each other on the DNA molecule. In addition, genes of R-groups of MD (GD), if projected to GD (MD) happen to be mostly found in one or several R-groups of the other type, although the kinetics of regulation may be different (e.g. group 9 of GD and group 12 of MD). However, in most cases similar patterns of regulation correspond to each other (15, 16 of GD correspond to 3, 4 of MD).
ER -
KOUTNÁ, Irena, Eva JANSOVÁ, Petr KRONTORÁD, Zbyněk SVOBODA, Tomáš PAVLÍK, Eva BÁRTOVÁ, Michal KOZUBEK and Stanislav KOZUBEK. Clustering of genes with similar regulation patterns during monocyte and granulocyte differentiation of HL-60 cells. In \textit{Biophysics of the Genome}. First Edition 2004. Brno: Masaryk University, 2004, p.~38-43. ISBN~80-210-3560-9.
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