| BÉBAROVÁ, Markéta, Peter MATEJOVIČ, Michal PÁSEK, Milena ŠIMURDOVÁ and Jiří ŠIMURDA. Effect of ajmaline on transient outward current Ito in rat ventricular myocytes. General Physiology and Biophysics. Bratislava: Slovak Academy of Sciences, 2005, vol. 24, No 1, p. 27-45. ISSN 0231-5882. |
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@article{564262,
author = {Bébarová, Markéta and Matejovič, Peter and Pásek, Michal and Šimurdová, Milena and Šimurda, Jiří},
article_location = {Bratislava},
article_number = {1},
keywords = {ajmaline; transient outward current; rat; frequency dependence},
language = {eng},
issn = {0231-5882},
journal = {General Physiology and Biophysics},
title = {Effect of ajmaline on transient outward current Ito in rat ventricular myocytes},
volume = {24},
year = {2005}
}
TY - JOUR
ID - 564262
AU - Bébarová, Markéta - Matejovič, Peter - Pásek, Michal - Šimurdová, Milena - Šimurda, Jiří
PY - 2005
TI - Effect of ajmaline on transient outward current Ito in rat ventricular myocytes
JF - General Physiology and Biophysics
VL - 24
IS - 1
SP - 27-45
EP - 27-45
PB - Slovak Academy of Sciences
SN - 02315882
KW - ajmaline
KW - transient outward current
KW - rat
KW - frequency dependence
N2 - The mechanism of ajmaline-induced inhibition of the transient outward current Ito has been investigated in right ventricular myocytes of rat using the whole cell patch clamp technique. Ajmaline decreased the amplitude and the time integral of Ito in a concentration-dependent, but frequency- and use-independent manner. We conclude that in the rat right ventricular myocytes ajmaline is an open channel blocker of Ito with fast recovery from the block at resting voltage.
ER -
BÉBAROVÁ, Markéta, Peter MATEJOVIČ, Michal PÁSEK, Milena ŠIMURDOVÁ and Jiří ŠIMURDA. Effect of ajmaline on transient outward current Ito in rat ventricular myocytes. \textit{General Physiology and Biophysics}. Bratislava: Slovak Academy of Sciences, 2005, vol.~24, No~1, p.~27-45. ISSN~0231-5882.
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