ČEŠKOVÁ, Eva, Tomáš NOVOTNÝ, A. FLORIÁNOVÁ, Vítězslav PÁLENSKÝ, Radovan PŘIKRYL and J. TOMANOVÁ. Safety and tolerability of second and third generation antipsychotic (Safety and tolerability of second and third gneration antipsychotic). Psychiatrie, časopis pro moderní psychiatrii. Praha: Tigis, 2004, vol. 8, Suppl.4, p. 16. ISSN 1211-7579.
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Basic information
Original name Safety and tolerability of second and third generation antipsychotic
Name (in English) Safety and tolerability of second and third gneration antipsychotic
Authors ČEŠKOVÁ, Eva (203 Czech Republic, guarantor), Tomáš NOVOTNÝ (203 Czech Republic), A. FLORIÁNOVÁ (203 Czech Republic), Vítězslav PÁLENSKÝ (203 Czech Republic), Radovan PŘIKRYL (203 Czech Republic) and J. TOMANOVÁ (203 Czech Republic).
Edition Psychiatrie, časopis pro moderní psychiatrii, Praha, Tigis, 2004, 1211-7579.
Other information
Original language Czech
Type of outcome Article in a journal
Field of Study 30000 3. Medical and Health Sciences
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
RIV identification code RIV/00216224:14110/04:00021295
Organization unit Faculty of Medicine
Keywords in English safety and tolerability; antipsychotics; QT interval
Tags antipsychotics, QT interval, safety and tolerability
Changed by Changed by: prof. MUDr. Eva Češková, CSc., učo 726. Changed: 12/12/2005 12:20.
Abstract
Prolongation of the QT interval is of concern since the pacients may be at risk for TdP, a serious ventricular arrythmia.In hospitalised psychiatric patients a 12-lead ECG was recorded, the QT interval was measured manually, the Bazett formula was used for correction. The total number of 375 ECG records was obtained. In 11 of 375 records(i.e.2,9%) the borderline or pathologics valuesof QT interval were found. The occurrence of abnormal QTc was lower than in so-far avilable literature. This could be connected with the change of spectrum of antipsychotics used, the general trend to lower doses of antipsychotics.
Abstract (in English)
Prolongation of the QT interval is of concern since the pacients may be at risk for TdP, a serious ventricular arrythmia.In hospitalised psychiatric patients a 12-lead ECG was recorded, the QT interval was measured manually, the Bazett formula was used for correction. The total number of 375 ECG records was obtained. In 11 of 375 records(i.e.2,9%) the borderline or pathologics valuesof QT interval were found. The occurrence of abnormal QTc was lower than in so-far avilable literature. This could be connected with the change of spectrum of antipsychotics used, the general trend to lower doses of antipsychotics.
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