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@article{564829,
author = {Pásek, Michal and Šimurda, Jiří},
article_number = {2},
keywords = {cardiac cell; sodium current block; propafenone; quantitative modelling},
language = {eng},
issn = {0140-0118},
journal = {Medical & Biological Engineering & Computing},
title = {Quantitative modelling of interaction of propafenone with sodium channels in cardiac cells},
volume = {42},
year = {2004}
}
TY - JOUR
ID - 564829
AU - Pásek, Michal - Šimurda, Jiří
PY - 2004
TI - Quantitative modelling of interaction of propafenone with sodium channels in cardiac cells
JF - Medical & Biological Engineering & Computing
VL - 42
IS - 2
SP - 151-157
EP - 151-157
PB - IFMBE
SN - 01400118
KW - cardiac cell
KW - sodium current block
KW - propafenone
KW - quantitative modelling
N2 - A mathematical model of the interaction of propafenone with cardiac sodium channels is based on experimental data that demonstrate use-dependent effect of the drug. The model of CLANCY and RUDY (Circulation, 2002; 105: 1208-1213) is applied to describe Na-channel in absence of the drug. The values of rate constants of the drug-receptor reaction are fitted to experimental data by iterative computer simulations using a genetic algorithm. The model suggests that drug molecules have an access to the binding sites predominantly in the inactivated states and that accumulation of blocked channels in the slow inactivated state is responsible for the observed use- dependent effects. The results of quantitative modelling predict that propafenone (0.2 mmol/l) effectively suppresses premature excitations leaving the regular action potentials nearly unaffected.
ER -
PÁSEK, Michal and Jiří ŠIMURDA. Quantitative modelling of interaction of propafenone with sodium channels in cardiac cells. \textit{Medical \&{} Biological Engineering \&{} Computing}. IFMBE, 2004, vol.~42, No~2, p.~151-157. ISSN~0140-0118.
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