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@inproceedings{565123,
author = {Pásek, Michal and Christé, Georges and Šimurda, Jiří},
address = {Svratka},
booktitle = {Engineering Mechanics 2004},
keywords = {cardiac cell; tubular system; quantitative modelling},
language = {eng},
location = {Svratka},
isbn = {80-85918-88-9},
pages = {1-9},
publisher = {Institute of Thermomechanics, Academy of Sciences of the Czech Republic},
title = {Ionic concentration changes in the tubular system of rat ventricular cardiac cell model},
year = {2004}
}
TY - JOUR
ID - 565123
AU - Pásek, Michal - Christé, Georges - Šimurda, Jiří
PY - 2004
TI - Ionic concentration changes in the tubular system of rat ventricular cardiac cell model
PB - Institute of Thermomechanics, Academy of Sciences of the Czech Republic
CY - Svratka
SN - 8085918889
KW - cardiac cell
KW - tubular system
KW - quantitative modelling
N2 - We present a design of a model of rat ventricular cardiomyocyte with transverse-axial tubular system and the results of the first simulations of tubular ionic concentration changes at different stimulation rates. The morphology of tubular system and the distribution of ionic channels in tubular membrane were described to meet the recent data of Soeller and Cannell (1999) and of Orchard's group in Leeds. Exploration of activity-dependent changes in tubular ionic concentrations revealed an increase in relative Ca2+ depletion from 7.3 % to 14 % when increasing the stimulation frequency from 1 Hz to 5 Hz. Meanwhile, relative K+ accumulation decreased from 4.3 % to 3 %. These effects led to a limitation of intracellular Ca2+ overload.
ER -
PÁSEK, Michal, Georges CHRISTÉ a Jiří ŠIMURDA. Ionic concentration changes in the tubular system of rat ventricular cardiac cell model. In \textit{Engineering Mechanics 2004}. Svratka: Institute of Thermomechanics, Academy of Sciences of the Czech Republic. s.~1-9. ISBN~80-85918-88-9. 2004.
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