PÁSEK, Michal, Georges CHRISTÉ and Jiří ŠIMURDA. Quantitative analysis of ionic concentration changes in tubular system of guinea pig ventricular cardiomyocyte. In Analysis of Biomedical Signals and Images. 17th ed. Brno: VUTIUM Press, 2004, p. 405-407. ISBN 80-214-2633-0.
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Basic information
Original name Quantitative analysis of ionic concentration changes in tubular system of guinea pig ventricular cardiomyocyte
Name in Czech Kvantitativní analýza iontově-koncentračních změn v tubulárním systému komorové buňky morčete
Authors PÁSEK, Michal (203 Czech Republic, guarantor), Georges CHRISTÉ (250 France) and Jiří ŠIMURDA (203 Czech Republic).
Edition 17. vyd. Brno, Analysis of Biomedical Signals and Images, p. 405-407, 3 pp. 2004.
Publisher VUTIUM Press
Other information
Original language English
Type of outcome Proceedings paper
Field of Study 10610 Biophysics
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
RIV identification code RIV/00216224:14110/04:00010870
Organization unit Faculty of Medicine
ISBN 80-214-2633-0
Keywords in English guinea pig; cardiac cell; tubular system; quantitative modelling
Tags Cardiac cell, guinea pig, Quantitative modelling, tubular system
Tags International impact, Reviewed
Changed by Changed by: doc. Ing. Michal Pásek, Ph.D., učo 46541. Changed: 2/1/2010 11:39.
Abstract
In this work, we explored the extent of ion concentration changes in the transverse-axial tubular system (TATS) of guinea pig ventricular cardiomyocyte. Computer simulations on a quantitative model revealed a decrease in relative Ca2+ depletion from 15.6 % to 7.1 % when the stimulation frequency increased from 1 Hz to 5 Hz. On the contrary, the relative K+ accumulation increased from 2.4 % to 3.4 %. The relative changes of tubular Na+ were negligible.
Abstract (in Czech)
Práce představuje výsledky simulací odhalující velikost iontově-koncentračních změn uvnitř transverzálně-axiálního tubulárního systému morčete a jejich frekvenční závislost.
Links
AV0Z2076919, plan (intention)Name: Dynamika tekutin, těles a jejich interakce
GP204/02/D129, research and development projectName: Kvantitativní analýza vlivu tubulárního systému na elektrickou aktivitu srdečních buněk
Investor: Czech Science Foundation, Quantitative analysis of effect of tubular system on electrical activity of cardiac cells
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