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@proceedings{565135,
author = {Pásek, Michal and Christé, Georges and Šimurda, Jiří},
booktitle = {4th International Symposium on Membrane Channels, Transporters and Receptors (Smolenice)},
keywords = {cardiac cell; tubular system; quantitative modelling},
language = {eng},
title = {Ion concentration changes in transverse-axial tubular system of rat and guinea pig ventricular cardiomyocytes: a simulation study},
year = {2004}
}
TY - CONF
ID - 565135
AU - Pásek, Michal - Christé, Georges - Šimurda, Jiří
PY - 2004
TI - Ion concentration changes in transverse-axial tubular system of rat and guinea pig ventricular cardiomyocytes: a simulation study
KW - cardiac cell
KW - tubular system
KW - quantitative modelling
N2 - We explored the extent of ion concentration changes in the transverse-axial tubular system (TATS) of rat and guinea pig ventricular cardiomyocytes by means of mathematical models. The simulations revealed significant changes of tubular calcium and potassium concentrations at different stimulation rates. In the rat model, the transient depletion of tubular Ca2+ increased from 7.3 % to 14 % (related to external level) and the transient accumulation of tubular K+ decreased from 4.3 % to 3 % with increase of stimulation rate from 1 Hz to 5 Hz. The guinea pig model, on the contrary, exhibited decrease of tubular Ca2+ depletion from 15.6 % to 7.1 % and increase of tubular K+ accumulation from 2.5 % to 3.4 % in the same frequency-range.
ER -
PÁSEK, Michal, Georges CHRISTÉ and Jiří ŠIMURDA. Ion concentration changes in transverse-axial tubular system of rat and guinea pig ventricular cardiomyocytes: a simulation study. In \textit{4th International Symposium on Membrane Channels, Transporters and Receptors (Smolenice)}. 2004.
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