Detailed Information on Publication Record
2004
Concentration changes in Ca2+ and K+ in the t-tubules of rat and guinea pig as estimated in two models of ventricular myocytes
CHRISTÉ, Georges, Michal PÁSEK, Jiří ŠIMURDA and Clive ORCHARDBasic information
Original name
Concentration changes in Ca2+ and K+ in the t-tubules of rat and guinea pig as estimated in two models of ventricular myocytes
Name in Czech
Koncentrační změny Ca2+ a K+ v t-tubulech potkana a morčete vyšetřené na dvou modelech ventrikulárních buněk
Authors
CHRISTÉ, Georges (250 France), Michal PÁSEK (203 Czech Republic, guarantor), Jiří ŠIMURDA (203 Czech Republic) and Clive ORCHARD (826 United Kingdom of Great Britain and Northern Ireland)
Edition
Meeting of The Physiological Society (Oxford), 2004
Other information
Language
English
Type of outcome
Konferenční abstrakt
Field of Study
10610 Biophysics
Country of publisher
United Kingdom of Great Britain and Northern Ireland
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
RIV identification code
RIV/00216224:14110/04:00028362
Organization unit
Faculty of Medicine
Keywords in English
cardiac cell; tubular system; quantitative modelling
Tags
International impact, Reviewed
Změněno: 2/1/2010 11:08, doc. Ing. Michal Pásek, Ph.D.
V originále
To explore the possible role of t-tubular system in the physiological modulation of cardiac electrical and contractile activity, we designed mathematical models of guinea pig and rat ventricular cardiomyocytes in which the t-tubules were described as a single compartment. In both models, action potential responses to brief stimulations in current clamp are accompanied by transient K+ accumulation and transient Ca2+ depletion in the t-tubule lumen. The amplitude of these changes, relative to external ion concentrations, was studied at steady state at frequencies of 1 to 5 Hz. In the rat model, Ca2+ depletion increased from 11.8 % to 20.8 % with stimulation frequency. Meanwhile, K+ accumulation decreased from 4.3 % to 3 %. On the contrary, the guinea pig model exhibited decrease of tubular Ca2+ depletion from 15.6 % to 7.1 % and increase of tubular K+ accumulation from 2.5 % to 3.4 % in the same frequency range.
In Czech
Práce prezentuje frekvenční závislosti iontově-koncentračních změn v transverzálně-axiálním tubulárním systému srdečních buněk laboratorního potkana a morčete získané prostřednictvím simulací na matematických modelech.
Links
| AV0Z2076919, plan (intention) |
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| GP204/02/D129, research and development project |
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