Other formats:
BibTeX
LaTeX
RIS
@proceedings{565167,
author = {Pásek, Michal and Christé, Georges and Šimurda, Jiří and Orchard, Clive},
booktitle = {Meeting of The Physiological Society (Oxford)},
keywords = {cardiac cell inotropy; tubular system; quantitative modelling},
language = {eng},
title = {Changes of [Ca2+] in the t-tubule lumen during activity may modulate the inotropic state of rat cardiac ventricular myocytes},
url = {http://www.physoc.org/custom/publications/proceedings/archive/article.asp?ID=J%20Physiol%20561PPC8},
year = {2004}
}
TY - CONF
ID - 565167
AU - Pásek, Michal - Christé, Georges - Šimurda, Jiří - Orchard, Clive
PY - 2004
TI - Changes of [Ca2+] in the t-tubule lumen during activity may modulate the inotropic state of rat cardiac ventricular myocytes
KW - cardiac cell inotropy
KW - tubular system
KW - quantitative modelling
UR - http://www.physoc.org/custom/publications/proceedings/archive/article.asp?ID=J%20Physiol%20561PPC8
N2 - The majority of trans-sarcolemmal Ca2+ flux occurs across the t-tubule membrane, which therefore plays a key role in cardiac excitation-contraction coupling; however Ca2+ within the t-tubules does not equilibrate instantaneously with the bulk extracellular solution. Thus, during activity, changes in [Ca2+] may occur within the t-tubule lumen, which would, in turn, alter trans-sarcolemmal Ca2+ flux. To test this hypothesis, we used a computer model of rat ventricular myocyte including a t-tubular system. The action potentials in the two membranes were not significantly different, reflecting the electrical coupling of the two compartments. However, [Ca2+] within the t-tubule lumen decreased on each stimulus, and decreased cumulatively, until reaching a new dynamic steady state, with increasing stimulation rate. These data suggest that activity-dependent depletion of Ca2+ within the t-tubule lumen, adjacent to the trans-sarcolemmal Ca2+ flux pathways, decreases the Ca load, and hence lowers the inotropic status, of ventricular myocytes.
ER -
PÁSEK, Michal, Georges CHRISTÉ, Jiří ŠIMURDA and Clive ORCHARD. Changes of [Ca2+] in the t-tubule lumen during activity may modulate the inotropic state of rat cardiac ventricular myocytes. In \textit{Meeting of The Physiological Society (Oxford)}. 2004.
|
